Search Results

Overview

Uniprot ID	Q567U6
Protein Name	Coiled-coil domain-containing protein 93
Gene Name	CCDC93
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
224	MEKAEDKKTALPAGL
571	EQIVEGIKQSRMKME

Function

Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947)

Protein Sequence

10 MGLPRGPEGQ 20 GLPEVETRED 30 EEQNVKLTEI 40 LELLVAAGYF 50 RARIKGLSPF 60 DKVVGGMTWC 70 ITTCNFDVDV 80 DLLFQENSTI 90 GQKIALSEKI 100 VSVLPRMKCP 110 HQLEPHQIQG 120 MDFIHIFPVV 130 QWLVKRAIET 140 KEEMGDYIRS 150 YSVSQFQKTY 160 SLPEDDDFIK 170 RKEKAIKTVV 180 DLSEVYKPRR 190 KYKRHQGAEE 200 LLDEESRIHA 210 TLLEYGRRYG 220 FSRQSKMEKA 230 EDKKTALPAG 240 LSATEKADAH 250 EEDELRAAEE 260 QRIQSLMTKM 270 TAMANEESRL 280 TASSVGQIVG 290 LCSAEIKQIV 300 SEYAEKQSEL 310 SAEESPEKLG 320 TSQLHRRKVI 330 SLNKQIAQKT 340 KHLEELRASH 350 TSLQARYNEA 360 KKTLTELKTY 370 SEKLDKEQAA 380 LEKIESKADP 390 SILQNLRALV 400 AMNENLKSQE 410 QEFKAHCREE 420 MTRLQQEIEN 430 LKAERAPRGD 440 EKTLSSGEPP 450 GTLTSAMTHD 460 EDLDRRYNME 470 KEKLYKIRLL 480 QARRNREIAI 490 LHRKIDEVPS 500 RAELIQYQKR 510 FIELYRQISA 520 VHKETKQFFT 530 LYNTLDDKKV 540 YLEKEISLLN 550 SIHENFSQAM 560 ASPAARDQFL 570 RQMEQIVEGI 580 KQSRMKMEKK 590 KQENKMRRDQ 600 LNDQYLELLE 610 KQRLYFKTVK 620 EFKEEGRKNE 630 MLLSKVKAKA S

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032991	protein-containing complex
Biological Process	GO:0032456	endocytic recycling
Biological Process	GO:0006893	Golgi to plasma membrane transport
Biological Process	GO:0015031	protein transport

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.