Search Results
Overview
| Uniprot ID | Q56P03 |
|---|---|
| Protein Name | E2F-associated phosphoprotein |
| Gene Name | EAPP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | DRAVQVTKKKKKKQH |
| 130 | KKKKKQHKIPTNDEL |
| 93 | GSSSGNGKVATAPTR |
Function
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression
Protein Sequence
10
MNRLPDDYDP
20
YAVEEPSDEE
30
PALSSSEDEV
40
DVLLHGTPDQ
50
KRKLIRECLT
60
GESESSSEDE
70
FEKEMEAELN
80
STMKTMEDKL
90
SSLGTGSSSG
100
NGKVATAPTR
110
YYDDIYFDSD
120
SEDEDRAVQV
130
TKKKKKKQHK
140
IPTNDELLYD
150
PEKDNRDQAW
160
VDAQRRGYHG
170
LGPQRSRQQQ
180
PVPNSDAVLN
190
CPACMTTLCL
200
DCQRHESYKT
210
QYRAMFVMNC
220
SINKEEVLRY
230
KASENRKKRR
240
VHKKMRSNRE
250
DAAEKAETDV
260
EEIYHPVMCT
270
ECSTEVAVYD
280
KDEVFHFFNV
LASHS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0034244 | negative regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.