Search Results
Overview
| Uniprot ID | Q570Y9 |
|---|---|
| Protein Name | DEP domain-containing mTOR-interacting protein |
| Gene Name | Deptor |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 48 | RLRLHEEKVIKDRRH |
Function
Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity
Protein Sequence
10
MEEGSSGGSG
20
SSDSNAGGSG
30
GVQQRELERM
40
AEVLVTGEQL
50
RLRLHEEKVI
60
KDRRHHLKTY
70
PNCFVAKELI
80
DWLIEHKEAS
90
DRETAIKLMQ
100
KLADRGIIHH
110
VCDEHKEFKD
120
VKLFYRFRKD
130
DGTFALDSEV
140
KAFMRGQRLY
150
EKLMSPETTL
160
LQPREEEGVK
170
YERTFMASEF
180
LDWLVQEGEA
190
TTRKEAEQLC
200
HRLMDHGIIQ
210
HVSNKHPFVD
220
SNLLYQFRMN
230
FRRRRRLMEL
240
LNETSPSSQE
250
THDSPFCLRK
260
QSHDSRKSTS
270
FMSVSPSKEI
280
KIVSAVRRSS
290
MSSCGSSGYF
300
SSSPTLSSSP
310
PVLCNPKSVL
320
KRPVTSEELL
330
TPGAPYARKT
340
FTIVGDAVGW
350
GFVVRGSKPC
360
HIQAVDPSGP
370
AAAAGMKVCQ
380
FVVSVNGLNV
390
LNVDYRTVSN
400
LILTGPRTIV
MEVMEELDC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0070300 | phosphatidic acid binding |
| Molecular Function | GO:0004860 | protein kinase inhibitor activity |
| Molecular Function | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| Biological Process | GO:0000045 | autophagosome assembly |
| Biological Process | GO:0031669 | cellular response to nutrient levels |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0010507 | negative regulation of autophagy |
| Biological Process | GO:0045792 | negative regulation of cell size |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0032007 | negative regulation of TOR signaling |
| Biological Process | GO:1904262 | negative regulation of TORC1 signaling |
| Biological Process | GO:1903940 | negative regulation of TORC2 signaling |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:2001236 | regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:0038202 | TORC1 signaling |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.