Search Results
Overview
| Uniprot ID | Q59J78 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 |
| Gene Name | Ndufaf2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 80 | AWIRRTRKTPPTMEE |
Function
Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone
Protein Sequence
10
MSWWSGVWRS
20
VWSALSREVR
30
EHVGTDHLGN
40
KYYYVAEYKN
50
WRGQTIREKR
60
IVEAANRKEV
70
DYEAGDIPTE
80
WEAWIRRTRK
90
TPPTMEEILK
100
NEKYREEIKI
110
KSQDFYEKDK
120
LGKETSEELL
130
PSPTATQVKG
140
HASAPYFGRE
150
EPSVAPTSTG
160
KTFQPGSWTP
EDGKRQSQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
| Biological Process | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.