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Overview

Uniprot IDQ5BJF6
Protein NameOuter dense fiber protein 2
Gene NameODF2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
126 KMNRYDKKIDSLMNA
138 MNAVGCLKSEVKMQK
142 GCLKSEVKMQKGERQ
159 KRFLEERKEELEEVA
187 RHNIERMKEEKDFTI
190 IERMKEEKDFTILQK
198 DFTILQKKHLQQEKE
210 EKECLMSKLVEAEMD
229 AKQVMALKDTIGKLK
239 IGKLKTEKQMTCTDI
253 INTLTRQKELLLQKL
259 QKELLLQKLSTFEET
295 EQQGALLKRLAEADS
304 LAEADSEKARLLLLL
333 QCEKAQAKTASELSK
340 KTASELSKSMESMRG
368 SRLCMQIKNLERSGN
49 KSHKRGMKGDTVNVR
505 TAEYSAFKLENERLK
521 SFAPMEDKLNQAHLE
537 QQLKASVKNYEGMID
547 EGMIDNYKSQVMKTR
552 NYKSQVMKTRLEADE
609 ILKITEAKLAECQDQ
62 VRRSVRVKTKVPWMP
64 RSVRVKTKVPWMPPG

Function

Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly

Protein Sequence

10 MSASSSGGSP 20 RFPSCGKNGV 30 TSLTQKKVLR 40 APCGAPSVTV 50 TKSHKRGMKG 60 DTVNVRRSVR 70 VKTKVPWMPP 80 GKSSARPVGC 90 KWENPPHCLE 100 ITPPSSEKLV 110 SVMRLSDLST 120 EDDDSGHCKM 130 NRYDKKIDSL 140 MNAVGCLKSE 150 VKMQKGERQM 160 AKRFLEERKE 170 ELEEVAHELA 180 ETEHENTVLR 190 HNIERMKEEK 200 DFTILQKKHL 210 QQEKECLMSK 220 LVEAEMDGAA 230 AAKQVMALKD 240 TIGKLKTEKQ 250 MTCTDINTLT 260 RQKELLLQKL 270 STFEETNRTL 280 RDLLREQHCK 290 EDSERLMEQQ 300 GALLKRLAEA 310 DSEKARLLLL 320 LQDKDKEVEE 330 LLQEIQCEKA 340 QAKTASELSK 350 SMESMRGHLQ 360 AQLRSKEAEN 370 SRLCMQIKNL 380 ERSGNQHKAE 390 VEAIMEQLKE 400 LKQKGDRDKE 410 SLKKAIRAQK 420 ERAEKSEEYA 430 EQLHVQLADK 440 DLYVAEALST 450 LESWRSRYNQ 460 VVKEKGDLEL 470 EIIVLNDRVT 480 DLVNQQQTLE 490 EKMREDRDSL 500 VERLHRQTAE 510 YSAFKLENER 520 LKASFAPMED 530 KLNQAHLEVQ 540 QLKASVKNYE 550 GMIDNYKSQV 560 MKTRLEADEV 570 AAQLERCDKE 580 NKILKDEMNK 590 EIEAARRQFQ 600 SQLADLQQLP 610 DILKITEAKL 620 AECQDQLQGY 630 ERKNIDLTAI 640 ISDLRSRIEH 650 QGDKLEMARE 660 KHQASQKENK 670 QLSLKVDELE 680 RKLEATSAQN 690 IEFLQVIAKR 700 EEAIHQSQLR 710 LEEKTRECGT 720 LARQLESAIE 730 DARRQVEQTK 740 EHALSKERAA 750 QNKILDLETQ 760 LSRTKTELSQ 770 LRRSRDDADR 780 RYQSRLQDLK 790 DRLEQSESTN 800 RSMQNYVQFL 810 KSSYANVFGD 820 GPYSTFLTSS PIRSRSPPA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0120103 centriolar subdistal appendage
Cellular Component GO:0005814 centriole
Cellular Component GO:0005813 centrosome
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0005929 cilium
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005634 nucleus
Cellular Component GO:0036126 sperm flagellum
Cellular Component GO:0097225 sperm midpiece
Cellular Component GO:0097228 sperm principal piece
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0010457 centriole-centriole cohesion
Biological Process GO:0044782 cilium organization
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:1902017 regulation of cilium assembly
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.