Search Results
Overview
| Uniprot ID | Q5BJP2 |
|---|---|
| Protein Name | Spliceosome-associated protein CWC15 homolog |
| Gene Name | Cwc15 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 18 | PARGGRGKGEGDLSQ |
| 28 | GDLSQLSKQYSSRDL |
| 40 | RDLPSHTKIKYRQTT |
| 91 | TTSSSVSKKPRLDQI |
Function
Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)
Protein Sequence
10
MTTAARPTFE
20
PARGGRGKGE
30
GDLSQLSKQY
40
SSRDLPSHTK
50
IKYRQTTQDA
60
PEEVRNRDFR
70
RELEERERAA
80
AREKNRDRPT
90
REHTTSSSVS
100
KKPRLDQIPA
110
ANLDADDPLT
120
DEEDEDFEEE
130
SDDDDTAALL
140
AELEKIKKER
150
AEEQARKEQE
160
QKAEEERIRM
170
ENILSGNPLL
180
NLTGPSQPQA
190
NFKVKRRWDD
200
DVVFKNCAKG
210
IDDQKKDKRF
220
VNDTLRSEFH
KKFMEKYIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071014 | post-mRNA release spliceosomal complex |
| Cellular Component | GO:0071020 | post-spliceosomal complex |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071018 | U12-type catalytic step 2 spliceosome |
| Cellular Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.