Search Results
Overview
| Uniprot ID | Q5BJT9 |
|---|---|
| Protein Name | Creatine kinase U-type, mitochondrial |
| Gene Name | Ckmt1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 140 | GYDPRTMKHTTDLDA |
| 149 | TTDLDASKIRSGYFD |
| 200 | VDALSGLKGDLAGRY |
| 276 | TRVISMEKGGNMKRV |
| 296 | RGLKEVEKLIQERGW |
| 332 | LRAGVHVKLPLLSKD |
| 338 | VKLPLLSKDSRFPKI |
| 403 | DCERRLEKGQDIRIP |
| 417 | PPPLVHGKH****** |
| 59 | AEYPDLRKHNNCMAS |
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
Protein Sequence
10
MAGPFSRLLS
20
ARPGLKLLAL
30
AGAGSLAAGI
40
LLRPESVRAA
50
TGERRRLYPP
60
SAEYPDLRKH
70
NNCMASHLTP
80
AVYARLCDKT
90
TPTGWTLDQC
100
IQTGVDNPGH
110
PFIKTVGMVA
120
GDEETYEVFA
130
ELFDPVIQER
140
HNGYDPRTMK
150
HTTDLDASKI
160
RSGYFDERYV
170
LSSRVRTGRS
180
IRGLSLPPAC
190
TRAERREVER
200
VVVDALSGLK
210
GDLAGRYYRL
220
SEMTEAEQQQ
230
LIDDHFLFDK
240
PVSPLLTAAG
250
MARDWPDARG
260
IWHNNEKSFL
270
IWVNEEDHTR
280
VISMEKGGNM
290
KRVFERFCRG
300
LKEVEKLIQE
310
RGWEFMWNER
320
LGYILTCPSN
330
LGTGLRAGVH
340
VKLPLLSKDS
350
RFPKILENLR
360
LQKRGTGGVD
370
TAATGSVFDI
380
SNLDRLGKSE
390
VELVQLVIDG
400
VNYLIDCERR
410
LEKGQDIRIP
PPLVHGKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004111 | creatine kinase activity |
| Biological Process | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| Biological Process | GO:0046314 | phosphocreatine biosynthetic process |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.