Search Results

Overview

Uniprot IDQ5BJZ3
Protein NameNAD(P) transhydrogenase, mitochondrial
Gene NameNnt
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1071 MLLGDAKKTCDALQA
1079 TCDALQAKVRESYQK
171 LNKLSERKTTVLAMD
290 EGQGGYAKEMSKEFI
294 GYAKEMSKEFIEAEM
403 LKAISPDKDNFHFEV
453 KEAPAKQKTVAELEA
49 LWCKSPAKPGIPYKQ
70 KEIFQNEKRVALSPA

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland

Protein Sequence

10 MAHLLKTVVT 20 GCLCPSVSNL 30 GSCKVLPGKK 40 DFLRTFRTHQ 50 ALWCKSPAKP 60 GIPYKQLTVG 70 VPKEIFQNEK 80 RVALSPAGVQ 90 ALVKQGFNVV 100 VESGAGEASK 110 FPDDLYRAAG 120 AQIQGTKEVL 130 ASDLVVKVRA 140 PMVNPTLGAH 150 EADFLKPSGT 160 LISFIYPAQN 170 PDLLNKLSER 180 KTTVLAMDQV 190 PRVTIAQGYD 200 ALSSMANISG 210 YKAVVLAANH 220 FGRFFTGQIT 230 AAGKVPPAKI 240 LIVGGGVAGL 250 ASAGAAKSMG 260 AVVRGFDTRA 270 AALEQFKSLG 280 AEPLEVDLKE 290 SGEGQGGYAK 300 EMSKEFIEAE 310 MKLFAQQCKE 320 VDILISTALI 330 PGKKAPVLFS 340 KEMIESMKEG 350 SVVVDLAAEA 360 GGNFETTKPG 370 ELYVHKGITH 380 IGYTDLPSRM 390 ATQASTLYSN 400 NITKLLKAIS 410 PDKDNFHFEV 420 KDDFDFGTMS 430 HVIRGTVVMK 440 DGNVIFPAPT 450 PKNIPKEAPA 460 KQKTVAELEA 470 EKAGTVSMYT 480 KTLRTASVYS 490 AGLTGMLGLG 500 IVAPNLAFSQ 510 MVTTFGLAGI 520 IGYHTVWGVT 530 PALHSPLMSV 540 TNAISGLTAV 550 GGLALMGGHF 560 YPSTTSQSLA 570 ALATFISSVN 580 IAGGFLVTQR 590 MLDMFKRPTD 600 PPEYNYLYLL 610 PGGTFVGGYL 620 AALYGGYNIE 630 EIMYLGSGLC 640 CVGALGGLST 650 QGTARLGNAL 660 GMIGVAGGLA 670 ATLGGLKPDP 680 QLLAQMSGAM 690 AMGGTIGLAI 700 AKRIQISDLP 710 QLVAAFHSLV 720 GLAAVLTCMA 730 EYIVEYPHFA 740 MDATSNFTKI 750 VAYIGTYIGG 760 VTFSGSLVAY 770 GKLQGILKSA 780 PLLLPGRHAL 790 NAGLLAASVG 800 GIIPFMADPS 810 FTTGIMCLGS 820 VSALSTLMGV 830 TLTAAIGGAD 840 MPVVITVLNS 850 YSGWALCAEG 860 FLLNNNLLTI 870 VGALIGSSGA 880 ILSYIMCVAM 890 NRSLANVILG 900 GYGTTSTAGG 910 KPMEISGTHT 920 EINLDNAVEM 930 IREANSIVIT 940 PGYGLCAAKA 950 QYPIADLVKM 960 LTEQGKKVRF 970 GIHPVAGRMP 980 GQLNVLLAEA 990 GVPYDIVLEM 1000 DEINSDFPDT 1010 DLVLVIGAND 1020 TVNSAAQEDP 1030 NSIIAGMPVL 1040 EVWKSKQVIV 1050 MKRSLGVGYA 1060 AVDNPIFYKP 1070 NTAMLLGDAK 1080 KTCDALQAKV RESYQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0050661 NADP binding
Molecular Function GO:0016491 oxidoreductase activity
Molecular Function GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity
Biological Process GO:0006740 NADPH regeneration

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.