Search Results
Overview
| Uniprot ID | Q5BK20 |
|---|---|
| Protein Name | Jupiter microtubule associated homolog 2 |
| Gene Name | Jpt2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | GADGQASKSGFRSMK |
| 176 | PRPRSHNKVLNPPGG |
Function
Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release. Confers NAADP-sensitivity to the two pore channels (TPCs) complex (By similarity). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062)
Protein Sequence
10
MFRGADGQAS
20
KSGFRSMKPP
30
GGESNDIFGS
40
PEEGVPSSKP
50
HRMASNIFGP
60
TEEPKNIPKR
70
TNPPGGKGSG
80
IFDESTPVQT
90
RQRLNPPGGK
100
TSDIFGSPVT
110
ATAPLAHPNK
120
PKDHVLLCEG
130
EDCKSDLKAA
140
TNSTPRGEQG
150
EKGSSTEAEP
160
AKIPEPIPTV
170
DSHEPRLGPR
180
PRSHNKVLNP
190
PGGKSSISFY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0075509 | endocytosis involved in viral entry into host cell |
| Biological Process | GO:0050848 | regulation of calcium-mediated signaling |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.