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Overview

Uniprot IDQ5FVI6
Protein NameV-type proton ATPase subunit C 1
Gene NameAtp6v1c1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
115 DMAKYPIKQSLKNIS
137 TQIDNDLKSRASAYN
147 ASAYNNLKGNLQNLE
21 TCQQTWEKLHAATTK
262 EEEMRADKEEMNRLS
274 RLSTDKKKQFGPLVR
28 KLHAATTKNNNLAVS
70 AFVEGVVKKVAQYMA
84 ADVLEDSKDKVQENL

Function

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity)

Protein Sequence

10 MTEFWLISAP 20 GEKTCQQTWE 30 KLHAATTKNN 40 NLAVSSKFNI 50 PDLKVGTLDV 60 LVGLSDELAK 70 LDAFVEGVVK 80 KVAQYMADVL 90 EDSKDKVQEN 100 LLASGVDLVT 110 YITRFQWDMA 120 KYPIKQSLKN 130 ISEIIAKGVT 140 QIDNDLKSRA 150 SAYNNLKGNL 160 QNLERKNAGS 170 LLTRSLAEIV 180 KKDDFVLDSE 190 YLVTLLVVVP 200 KLNHNDWIKQ 210 YETLAEMVVP 220 RSSNVLSEDQ 230 DSYLCNVTLF 240 KKAVDDFRHK 250 ARENKFIVRD 260 FQYNEEEMRA 270 DKEEMNRLST 280 DKKKQFGPLV 290 RWLKVNFSEA 300 FIAWIHIKAL 310 RVFVESVLRY 320 GLPVNFQAML 330 LQPNKKSVKK 340 LREVLHELYK 350 HLDSSAAAII 360 DAPMDIPGLN 370 LSQQEYYPYV 380 YYKIDCNLLE FK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0098850 extrinsic component of synaptic vesicle membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0033176 proton-transporting V-type ATPase complex
Cellular Component GO:0033180 proton-transporting V-type ATPase, V1 domain
Cellular Component GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:0097401 synaptic vesicle lumen acidification

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.