Overview
| Uniprot ID | Q5FVJ0 |
|---|
| Protein Name | Protein RUFY3 |
|---|
| Gene Name | Rufy3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 350 |
SEARKHLKEETQLRL |
| 405 |
LDDLRALKHELAFKL |
| 420 |
QSSDLGVKQKSELNS |
| 432 |
LNSRLEEKTNQMAAT |
Function
ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (By similarity). Plays a role in the generation of neuronal polarity formation and axon growth (PubMed:17439943). Implicated in the formation of a single axon by developing neurons (PubMed:17439943). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (PubMed:17439943). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (By similarity). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity)
Protein Sequence
10
MSALTPPTDM
20
PTPTTDKITQ
30
AAMETIYLCK
40
FRVSMDGEWL
50
CLRELDDISL
60
TPDPEPTHED
70
PNYLMANERM
80
NLMNMAKLSI
90
KGLIESALNL
100
GRTLDSDYAP
110
LQQFFVVMEH
120
CLKHGLKAKK
130
TFLGQNKSFW
140
GPLELVEKLV
150
PEAAEITASV
160
KDLPGLKTPV
170
GRGRAWLRLA
180
LMQKKLSEYM
190
KALINKKELL
200
SEFYEANALM
210
MEEEGAIIAG
220
LLVGLNVIDA
230
NFCMKGEDLD
240
SQVGVIDFSM
250
YLKDGNSSKG
260
SEGDGQITAI
270
LDQKNYVEEL
280
NRHLNATVNN
290
LQAKVDALEK
300
SNTKLTEELA
310
VANNRIITLQ
320
EEMERVKEES
330
SYLLESNRKG
340
PKQDRTAEGQ
350
ALSEARKHLK
360
EETQLRLDVE
370
KELELQISMR
380
QEMELAMKML
390
EKDVCEKQDA
400
LVSLRQQLDD
410
LRALKHELAF
420
KLQSSDLGVK
430
QKSELNSRLE
440
EKTNQMAATI
450
KQLEQSEKDL
460
VKQAKTLNSA
ANKLIPKHH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0036019 |
endolysosome |
| Cellular Component |
GO:0030175 |
filopodium |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0043204 |
perikaryon |
| Molecular Function |
GO:0034452 |
dynactin binding |
| Biological Process |
GO:0007015 |
actin filament organization |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0050771 |
negative regulation of axonogenesis |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:0045773 |
positive regulation of axon extension |
| Biological Process |
GO:0050772 |
positive regulation of axonogenesis |
| Biological Process |
GO:0030335 |
positive regulation of cell migration |
| Biological Process |
GO:0090316 |
positive regulation of intracellular protein transport |
| Biological Process |
GO:2001019 |
positive regulation of retrograde axon cargo transport |
| Biological Process |
GO:0050770 |
regulation of axonogenesis |
| Biological Process |
GO:2000114 |
regulation of establishment of cell polarity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.