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Overview

Uniprot IDQ5FVQ8
Protein NameNLR family member X1
Gene NameNlrx1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
299 AIGRIPSKYVGRYGE
657 LENAQAIKKKLGKMG

Function

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)

Protein Sequence

10 MRWGCHLPRT 20 SWGSGLGRTV 30 PLPDELRIQS 40 SWPFKGVHHP 50 LRPPRAFIRH 60 HGNSADSAPP 70 PGRHGQLFRS 80 ISATEAIQRH 90 RRNLTEWFSR 100 LPREERQFGP 110 TFALDTVHVD 120 PVIRESTPDD 130 LLRPSTELAT 140 GHQRTQAELP 150 PLALSQLFDP 160 DACGRRVQTV 170 VLYGTVGTGK 180 STLVRKMVLD 190 WCYGRLPAFE 200 LLIPFSCEDL 210 SSLGSTPASL 220 CQLVTQRYTP 230 LKEVLPLMNA 240 AGSRLLFVLH 250 GLERLNLDFR 260 LAGTGLCSDP 270 EEPGAPAAIM 280 VNLLRKYMLP 290 EASILVTTRP 300 SAIGRIPSKY 310 VGRYGEICGF 320 SDTNLQKLYF 330 QLRLNQPDCG 340 YGAGGTGVSV 350 TPAQRDNLIQ 360 MLSRNLEGHH 370 QIAAACFLPS 380 YCWLVCATLH 390 FLHAPTSAGQ 400 TLTSIYTSFL 410 RLNFNGETLD 420 STDPSNLSLM 430 SYAARTMGKL 440 AYEGVSSRKT 450 YFSEEDVRGC 460 LEAGIKTEEE 470 FQLLQIFRRD 480 ALRFFLAPCV 490 EPGHLGTFVF 500 TVPAMQEYLA 510 ALYIVLGLRK 520 TALQRVGKEV 530 FEFVGRVGED 540 VSLVLGIVAK 550 LLPLRILPLL 560 FNLLKVVPRV 570 FGRMVSKSRE 580 AVAQAMVLEM 590 FREEDYYNDD 600 VLDQMGASIL 610 GVEGPRRHPD 620 EPPEDEVFEL 630 FPMFMSGLLS 640 AHNRAVLAQL 650 GCPIKNLDAL 660 ENAQAIKKKL 670 GKMGRQVLPP 680 SELLDHLFFH 690 YEFQNQRFSA 700 EVLGSLRQLN 710 LAGVRMTPLK 720 CTVVASVLGS 730 GRHPLDEVNL 740 ASCQLDPAGL 750 HTLMPVLLRA 760 RKLGLQLNNL 770 GPEACRDLRD 780 LLLHDQCQIT 790 TLRLSNNPLT 800 AAGVGVLMDG 810 LAGNTSVTHL 820 SLLHTDLGDE 830 GLELLAAQLD 840 RNKQLQELNV 850 AYNGAGDTVA 860 LALAKAARKH 870 PSLELLHLYF 880 NELSSEGRQV 890 LRDLGGSGEG 900 GARVVASLTE 910 GTAVSEYWSV 920 ILSEVQRNLN 930 SWDPVRVQRH 940 LKLLLRDLED 950 SRGATLNPWR 960 KAQLLRVESE 970 VKTLLEQLGG SGH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Biological Process GO:0045087 innate immune response
Biological Process GO:0043124 negative regulation of canonical NF-kappaB signal transduction
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0045824 negative regulation of innate immune response
Biological Process GO:0032688 negative regulation of interferon-beta production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0039536 negative regulation of RIG-I signaling pathway

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.