Search Results
Overview
| Uniprot ID | Q5FWF5 |
|---|---|
| Protein Name | N-acetyltransferase ESCO1 |
| Gene Name | ESCO1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 258 | MATSVVPKKNEMKKS |
Function
Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053)
Protein Sequence
10
MMSIQEKSKE
20
NSSKVTKKSD
30
DKNSETEIQD
40
SQKNLAKKSG
50
PKETIKSQAK
60
SSSESKINQP
70
ELETRMSTRS
80
SKAASNDKAT
90
KSINKNTVTV
100
RGYSQESTKK
110
KLSQKKLVHE
120
NPKANEQLNR
130
RSQRLQQLTE
140
VSRRSLRSRE
150
IQGQVQAVKQ
160
SLPPTKKEQC
170
SSTQSKSNKT
180
SQKHVKRKVL
190
EVKSDSKEDE
200
NLVINEVINS
210
PKGKKRKVEH
220
QTACACSSQC
230
TQGSEKCPQK
240
TTRRDETKPV
250
PVTSEVKRSK
260
MATSVVPKKN
270
EMKKSVHTQV
280
NTNTTLPKSP
290
QPSVPEQSDN
300
ELEQAGKSKR
310
GSILQLCEEI
320
AGEIESDNVE
330
VKKESSQMES
340
VKEEKPTEIK
350
LEETSVERQI
360
LHQKETNQDV
370
QCNRFFPSRK
380
TKPVKCILNG
390
INSSAKKNSN
400
WTKIKLSKFN
410
SVQHNKLDSQ
420
VSPKLGLLRT
430
SFSPPALEMH
440
HPVTQSTFLG
450
TKLHDRNITC
460
QQEKMKEINS
470
EEVKINDITV
480
EINKTTERAP
490
ENCHLANEIK
500
PSDPPLDNQM
510
KHSFDSASNK
520
NFSQCLESKL
530
ENSPVENVTA
540
ASTLLSQAKI
550
DTGENKFPGS
560
APQQHSILSN
570
QTSKSSDNRE
580
TPRNHSLPKC
590
NSHLEITIPK
600
DLKLKEAEKT
610
DEKQLIIDAG
620
QKRFGAVSCN
630
VCGMLYTASN
640
PEDETQHLLF
650
HNQFISAVKY
660
VGWKKERILA
670
EYPDGRIIMV
680
LPEDPKYALK
690
KVDEIREMVD
700
NDLGFQQAPL
710
MCYSRTKTLL
720
FISNDKKVVG
730
CLIAEHIQWG
740
YRVIEEKLPV
750
IRSEEEKVRF
760
ERQKAWCCST
770
LPEPAICGIS
780
RIWVFSMMRR
790
KKIASRMIEC
800
LRSNFIYGSY
810
LSKEEIAFSD
820
PTPDGKLFAT
830
QYCGTGQFLV
840
YNFINGQNST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0016407 | acetyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008080 | N-acetyltransferase activity |
| Molecular Function | GO:0061733 | protein-lysine-acetyltransferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0007064 | mitotic sister chromatid cohesion |
| Biological Process | GO:0018394 | peptidyl-lysine acetylation |
| Biological Process | GO:0034421 | post-translational protein acetylation |
| Biological Process | GO:0006275 | regulation of DNA replication |
| Biological Process | GO:0007062 | sister chromatid cohesion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.