Search Results
Overview
| Uniprot ID | Q5FWT1 |
|---|---|
| Protein Name | Protein FAM98A |
| Gene Name | Fam98a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 133 | CVNAPPKKAQEGGGS |
| 296 | KTACAINKVLMGRVP |
Function
Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts
Protein Sequence
10
MECDLMETDI
20
LESLEDLGYK
30
GPLLDDGALL
40
QAVSAGAASP
50
EFTKLCAWLV
60
SELRVLCKLE
70
ENVQATNSPS
80
EAEEFQLEVS
90
GLLGEMNCPY
100
PCLTSGDVTK
110
RLLVQKNCLL
120
LLTYLISELE
130
AARMLCVNAP
140
PKKAQEGGGS
150
EVFQELKGIC
160
IALGMSKPPA
170
NITMFQFFSG
180
IEKKLKETLA
190
KVPPNHVGKP
200
LLKKSMGPAH
210
WEKIEAINQA
220
IANEYEVRRK
230
LLIKRLDVTV
240
QSFGWSDRAK
250
SQTEKLAKVY
260
QPKRSVLSPK
270
GNISIAHLLA
280
ARQDLSKILR
290
TSSGSIREKT
300
ACAINKVLMG
310
RVPDRGGRPN
320
EIEPPPPEMP
330
PWQKRQDGPQ
340
QQAGGRGGGR
350
GGYEHSSYGG
360
RGGHEQGGRG
370
GRGGYDHGGR
380
GGGRGNKHQG
390
GWTDGGSASG
400
GGYQDGGYRD
410
PGFQPGGYHG
420
GHSSGYQGGG
430
YGGFQTSSYT
440
GSGYQGGGYQ
450
QDNRYQDGGH
460
HGERGSGRGG
470
RGGRGGRGGR
480
GSQGGGWGGR
490
GSQTYHQGGQ
500
FEQHFQHGGY
510
QYSHSGFGQG
RHYTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0072669 | tRNA-splicing ligase complex |
| Molecular Function | GO:0008276 | protein methyltransferase activity |
| Biological Process | GO:0032418 | lysosome localization |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0006479 | protein methylation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.