Search Results
Overview
| Uniprot ID | Q5G6V9 |
|---|---|
| Protein Name | Cofilin-2 |
| Gene Name | CFL2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 22 | FNDMKVRKSSTQEEI |
| 30 | SSTQEEIKKRKKAVL |
| 44 | LFCLSDDKRQIIVEE |
Function
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity)
Protein Sequence
10
MASGVTVNDE
20
VIKVFNDMKV
30
RKSSTQEEIK
40
KRKKAVLFCL
50
SDDKRQIIVE
60
EAKQILVGDI
70
GDTVEDPYTS
80
FVKLLPLNDC
90
RYALYDATYE
100
TKESKKEDLV
110
FIFWAPESAP
120
LKSKMIYASS
130
KDAIKKKFTG
140
IKHEWQVNGL
150
DDIKDRSTLG
160
EKLGGNVVVS
LEGKPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0030043 | actin filament fragmentation |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0030836 | positive regulation of actin filament depolymerization |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.