Search Results
Overview
| Uniprot ID | Q5HYI8 |
|---|---|
| Protein Name | Rab-like protein 3 |
| Gene Name | RABL3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 231 | RFGAGTLKSLHYD** |
Function
Small GTPase required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (PubMed:31406347). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity). Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis (PubMed:36052645)
Protein Sequence
10
MASLDRVKVL
20
VLGDSGVGKS
30
SLVHLLCQNQ
40
VLGNPSWTVG
50
CSVDVRVHDY
60
KEGTPEEKTY
70
YIELWDVGGS
80
VGSASSVKST
90
RAVFYNSVNG
100
IIFVHDLTNK
110
KSSQNLRRWS
120
LEALNRDLVP
130
TGVLVTNGDY
140
DQEQFADNQI
150
PLLVIGTKLD
160
QIHETKRHEV
170
LTRTAFLAED
180
FNPEEINLDC
190
TNPRYLAAGS
200
SNAVKLSRFF
210
DKVIEKRYFL
220
REGNQIPGFP
230
DRKRFGAGTL
KSLHYD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0003925 | G protein activity |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0030183 | B cell differentiation |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0001779 | natural killer cell differentiation |
| Biological Process | GO:0045724 | positive regulation of cilium assembly |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:1903059 | regulation of protein lipidation |
| Biological Process | GO:0046578 | regulation of Ras protein signal transduction |
| Biological Process | GO:0033077 | T cell differentiation in thymus |
Reference
PMID: N/A