Search Results
Overview
| Uniprot ID | Q5HYJ3 |
|---|---|
| Protein Name | Protein FAM76B |
| Gene Name | FAM76B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 325 | KQVAALSKGKKFDKS |
Function
Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448)
Protein Sequence
10
MAASALYACT
20
KCTQRYPFEE
30
LSQGQQLCKE
40
CRIAHPIVKC
50
TYCRSEFQQE
60
SKTNTICKKC
70
AQNVKQFGTP
80
KPCQYCNIIA
90
AFIGTKCQRC
100
TNSEKKYGPP
110
QTCEQCKQQC
120
AFDRKEEGRR
130
KVDGKLLCWL
140
CTLSYKRVLQ
150
KTKEQRKSLG
160
SSHSNSSSSS
170
LTEKDQHHPK
180
HHHHHHHHHH
190
RHSSSHHKIS
200
NLSPEEEQGL
210
WKQSHKSSAT
220
IQNETPKKKP
230
KLESKPSNGD
240
SSSINQSADS
250
GGTDNFVLIS
260
QLKEEVMSLK
270
RLLQQRDQTI
280
LEKDKKLTEL
290
KADFQYQESN
300
LRTKMNSMEK
310
AHKETVEQLQ
320
AKNRELLKQV
330
AALSKGKKFD
KSGSILTSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0048255 | mRNA stabilization |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0043031 | negative regulation of macrophage activation |
| Biological Process | GO:0046826 | negative regulation of protein export from nucleus |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.