Search Results
Overview
| Uniprot ID | Q5HYK7 |
|---|---|
| Protein Name | SH3 domain-containing protein 19 |
| Gene Name | SH3D19 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 562 | IPEGGNGKRECVSSH |
Function
May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding (PubMed:15280379). May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 (PubMed:14551139). Required for regulation of cell morphology and cytoskeletal organization (PubMed:21834987)
Protein Sequence
10
MNIMNTEQSQ
20
NSIVSRIKVF
30
EGQTNIETSG
40
LPKKPEITPR
50
SLPPKPTVSS
60
GKPSVAPKPA
70
ANRASGEWDS
80
GTENRLKVTS
90
KEGLTPYPPL
100
QEAGSIPVTK
110
PELPKKPNPG
120
LIRSVNPEIP
130
GRGPLAESSD
140
SGKKVPTPAP
150
RPLLLKKSVS
160
SENPTYPSAP
170
LKPVTVPPRL
180
AGASQAKAYK
190
SLGEGPPANP
200
PVPVLQSKPL
210
VDIDLISFDD
220
DVLPTPSGNL
230
AEESVGSEMV
240
LDPFQLPAKT
250
EPIKERAVQP
260
APTRKPTVIR
270
IPAKPGKCLH
280
EDPQSPPPLP
290
AEKPIGNTFS
300
TVSGKLSNVE
310
RTRNLESNHP
320
GQTGGFVRVP
330
PRLPPRPVNG
340
KTIPTQQPPT
350
KVPPERPPPP
360
KLSATRRSNK
370
KLPFNRSSSD
380
MDLQKKQSNL
390
ATGLSKAKSQ
400
VFKNQDPVLP
410
PRPKPGHPLY
420
SKYMLSVPHG
430
IANEDIVSQN
440
PGELSCKRGD
450
VLVMLKQTEN
460
NYLECQKGED
470
TGRVHLSQMK
480
IITPLDEHLR
490
SRPNDPSHAQ
500
KPVDSGAPHA
510
VVLHDFPAEQ
520
VDDLNLTSGE
530
IVYLLEKIDT
540
DWYRGNCRNQ
550
IGIFPANYVK
560
VIIDIPEGGN
570
GKRECVSSHC
580
VKGSRCVARF
590
EYIGEQKDEL
600
SFSEGEIIIL
610
KEYVNEEWAR
620
GEVRGRTGIF
630
PLNFVEPVED
640
YPTSGANVLS
650
TKVPLKTKKE
660
DSGSNSQVNS
670
LPAEWCEALH
680
SFTAETSDDL
690
SFKRGDRIQI
700
LERLDSDWCR
710
GRLQDREGIF
720
PAVFVRPCPA
730
EAKSMLAIVP
740
KGRKAKALYD
750
FRGENEDELS
760
FKAGDIITEL
770
ESVDDDWMSG
780
ELMGKSGIFP
790
KNYIQFLQIS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0070064 | proline-rich region binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.