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Overview

Uniprot IDQ5HZB6
Protein NameCLK4-associating serine/arginine rich protein
Gene NameClasrp
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
547 ASPAVGEKLKKTEPA
565 ETGAAKPKLTPQERL
578 RLKLRMQKALNRQFK

Function

Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity)

Protein Sequence

10 MWHEARKHER 20 KLRGMMVDYK 30 KRAERRREYY 40 EKIKKDPAQF 50 LQVHGRACKV 60 HLDSAVALAA 70 ESPVNMMPWQ 80 GDTNNMIDRF 90 DVRAHLDHIP 100 DYTPPLLTTI 110 SPEQESDERK 120 CNYERYRGLV 130 QNDFAGISEE 140 QCLYQIYIDE 150 LYGGLQRPSE 160 DEKKKLAEKK 170 ASIGYTYEDS 180 TVAEVEKVAE 190 KPEEEESPAE 200 EESNSDEDEV 210 IPDIDVEVDV 220 DELNQEQVAD 230 LNKQATTYGM 240 ADGDFVRMLR 250 KDKEEAEAIK 260 HAKALEEEKA 270 MYSGRRSRRQ 280 RREFREKRLR 290 GRKISPPSYA 300 RRDSPTYDPY 310 KRSPSESSSE 320 SRSRSRSPSP 330 GREEKITFIT 340 SFGGSDEEAA 350 AAAAAAAASG 360 AAPGKPPAPP 370 QPGGPAPGRN 380 ASARRRSSSS 390 SASRTSSSRS 400 SSRSSSRSRR 410 GYYRSGRHAR 420 SRSRSWSRSR 430 SRSRRYSRSR 440 SRGRRHSDGG 450 SRDGHRYSRS 460 PARRSGYAPR 470 RRSRSRSRSG 480 DRYKRGARGP 490 RHHSSSHSRS 500 SWSLSPSRSR 510 SLTRSGSRSQ 520 SRSRSRSQSH 530 SQSQSHSPSP 540 PREKLTRPAA 550 SPAVGEKLKK 560 TEPAAGKETG 570 AAKPKLTPQE 580 RLKLRMQKAL 590 NRQFKADKKA 600 AQEKMIQQEH 610 ERQEREDELR 620 AMARKIRMKE 630 RERREKEREE 640 WERQYSRQSR 650 SPSPRYSREY 660 SSSRRRSRSR SRSPHYRH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.