Search Results
Overview
| Uniprot ID | Q5HZI9 |
|---|---|
| Protein Name | Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 |
| Gene Name | Slc25a51 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 154 | QDHKHHDKFTNTYQA |
Function
Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria. The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated
Protein Sequence
10
MMDSEAHEKR
20
PPMLTSSNQD
30
LSPHIAGVGD
40
MKHYLCGYCA
50
AFNNVAITYP
60
VQKILFRQQL
70
YGIKTRDAVL
80
QLRKDGFRNL
90
YRGILPPLMQ
100
KTTTLALMFG
110
LYEDLSRLLH
120
KHVSSAPEFA
130
TRSVAALLAG
140
TTEAILTPFE
150
RVQTLLQDHK
160
HHDKFTNTYQ
170
AFRALRCHGI
180
AEYYRGMVPI
190
LFRNGFGNVL
200
FFGLRGPIKE
210
SLPTATTYSA
220
HLVNDFICGG
230
VLGAVLGFLS
240
FPINVVKARI
250
QSQIGGPFLS
260
LPMVFKTIWI
270
ERDRKLINLF
280
RGAHLNYHRS
290
LISWGIINAT
YEFLLKIV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051724 | NAD transmembrane transporter activity |
| Biological Process | GO:0019646 | aerobic electron transport chain |
| Biological Process | GO:1990549 | mitochondrial NAD transmembrane transport |
| Biological Process | GO:0034355 | NAD+ biosynthetic process via the salvage pathway |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.