Search Results
Overview
| Uniprot ID | Q5HZY0 |
|---|---|
| Protein Name | UBX domain-containing protein 4 |
| Gene Name | Ubxn4 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 232 | IERRKTGKEMLDYKR |
| 268 | RAARERIKQQIALDR |
| 292 | TKEAEAAKAAALLAK |
Function
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD
Protein Sequence
10
MLWFQGAIPA
20
AIASAKRSGA
30
VFVVFVAGDD
40
EQSTQMAASW
50
EDEKVREASS
60
DNFVAIKIDT
70
KSEACLQFSQ
80
IYPVVCVPSS
90
FFIGDSGIPL
100
EVIAGSVSAD
110
ELVTRIHKVQ
120
QMHSLKGETS
130
VTNDKQSESS
140
VSTPSASFEP
150
DICESAESRN
160
TELCETPTTS
170
DPKSDTAAGG
180
ECAGHDSLSQ
190
EPPGCSNQRP
200
AEDLTVRVER
210
LTKKLEERRE
220
EKRKEEAQRE
230
IKKEIERRKT
240
GKEMLDYKRK
250
QEEELTKRML
260
EERSREKAED
270
RAARERIKQQ
280
IALDRAERAA
290
RFAKTKEAEA
300
AKAAALLAKQ
310
AEAEVKRESS
320
TRDRSTIARI
330
QFRLPDGSSF
340
TNQFPSDAPL
350
EEARQFAAQT
360
VGNTYGNFSL
370
ATMFPRREFT
380
REDYKRKLLD
390
LELAPSASVV
400
LLPAGRPATS
410
IVPSSSGDIW
420
TLLGTVLYPF
430
LAIWRLISNF
440
LFSNPPPAQT
450
SARATSTEPS
460
NSASSSKSEK
470
REPVRKRVLE
480
KRGEDFKKEG
490
KIYRLRTQDD
500
GEDENNTWNG
NSTQQM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0006986 | response to unfolded protein |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.