Search Results
Overview
| Uniprot ID | Q5I0E3 |
|---|---|
| Protein Name | Cholesin |
| Gene Name | Chlsn |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 20 | AKESKKQKITPAEET |
Function
Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146
Protein Sequence
10
MVKQKRKGLE
20
RTAKESKKQK
30
ITPAEETPRA
40
SEARPGKEAA
50
SPVVQEASPE
60
LSPEERRVLE
70
RKLKKERKKE
80
EKKRLREAGI
90
ATAQTAKVQT
100
PPAKPSAAVL
110
ALEYLQGWAE
120
KQESWRFQKT
130
RQTWLLLHMY
140
DEDKVPEQHF
150
STLLDYLEGL
160
RGSARELTVQ
170
KAETLMQELD
180
GTDPKARSLG
190
KMQRLRQVLQ
LLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005179 | hormone activity |
| Biological Process | GO:0045541 | negative regulation of cholesterol biosynthetic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.