Overview
| Uniprot ID | Q5I0E7 |
|---|
| Protein Name | Transmembrane emp24 domain-containing protein 9 |
|---|
| Gene Name | Tmed9 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 160 |
AEIAAKDKLSELQLR |
| 71 |
YRTQLYDKQREEYQP |
Function
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity)
Protein Sequence
10
MAAVRGVRVV
20
GTSPGLLLGR
30
GMRAFLLLLC
40
LAARGGALYF
50
HIGETEKKCF
60
IEEIPDETMV
70
IGNYRTQLYD
80
KQREEYQPAT
90
PGLGMFVEVK
100
DPEDKVILAR
110
QYGSEGRFTF
120
TSHTPGEHQI
130
CLHSNSTKFS
140
LFAGGMLRVH
150
LDIQVGEHAN
160
DYAEIAAKDK
170
LSELQLRVRQ
180
LVEQVEQIQK
190
EQNYQRWREE
200
RFRQTSESTN
210
QRVLWWSILQ
220
TLILVAIGVW
230
QMRHLKSFFE
AKKLV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030134 |
COPII-coated ER to Golgi transport vesicle |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005793 |
endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component |
GO:0033116 |
endoplasmic reticulum-Golgi intermediate compartment membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0019905 |
syntaxin binding |
| Biological Process |
GO:0048205 |
COPI coating of Golgi vesicle |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0006886 |
intracellular protein transport |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.