Search Results
Overview
| Uniprot ID | Q5I0G4 |
|---|---|
| Protein Name | Glycine--tRNA ligase |
| Gene Name | Gars1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | KELALQPKDDIVDRA |
| 88 | DRAVAELKARKRVLE |
| 97 | RKRVLEAKELALQPK |
Function
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis
Protein Sequence
10
MPCLLPTLLR
20
ATRAALLLQS
30
PRVVAAPASQ
40
RLLSAPAQPA
50
ASPSSMDSAE
60
ELLAPLRLAV
70
RQQGDFVRKL
80
KEDKAPQVDV
90
DRAVAELKAR
100
KRVLEAKELA
110
LQPKDDIVDR
120
AKMEDTLKRR
130
FFYDQAFAIY
140
GGVSGLYDFG
150
PVGCALKNNI
160
IQTWRQHFIQ
170
EEQILEIDCT
180
MLTPEPVLKT
190
SGHVDKFADF
200
MVKDVKNGEC
210
FRADHLLKAH
220
LQKLMSDKKC
230
SAEKKSEMES
240
VLAQLDNYGQ
250
QELADLFVNY
260
NVKSPTTGND
270
LSPPVPFNLM
280
FQTFIGPGGN
290
MPGYLRPETA
300
QGIFLNFKRL
310
LEFNQGKLPF
320
AAAQIGNSFR
330
NEISPRSGLI
340
RVREFTMAEI
350
EHFVDPTEKD
360
HPKFPSVADL
370
YLYLYSAKAQ
380
VTGQSARKMR
390
LGDAVEQGVI
400
NNSVLGYFIG
410
RIYLYLTKVG
420
ISPDKLRFRQ
430
HMENEMAHYA
440
CDCWDAESKT
450
SYGWIEIVGC
460
ADRSCYDLSC
470
HARATKVPLV
480
AEKPLKEPKT
490
VNVVQFEPNK
500
GAVGKAYKKD
510
AKLVLEYLGA
520
CDECYITEME
530
LLLSEKGEFT
540
IETEGKTFQL
550
TKDMVSVKRF
560
QKTLHVEEVV
570
PSVIEPSFGL
580
GRIMYTILEH
590
TFHVREGDEQ
600
RTFFSFPAVV
610
APFKCSVLPL
620
SQNQEFMPFV
630
KELSEALTRN
640
GVSHKVDDSS
650
GSIGRRYART
660
DEIGVAFGIT
670
IDFDTVNKTP
680
HTATLRDRDS
690
MRQIRAEVSE
700
LPSVVRDLAN
710
GNITWADVEA
720
RYPLFEGQET
GKKETVEE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0030141 | secretory granule |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0141192 | ATP:ATP adenylyltransferase activity |
| Molecular Function | GO:0004081 | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
| Molecular Function | GO:0004820 | glycine-tRNA ligase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Biological Process | GO:0015966 | diadenosine tetraphosphate biosynthetic process |
| Biological Process | GO:0006426 | glycyl-tRNA aminoacylation |
| Biological Process | GO:0070150 | mitochondrial glycyl-tRNA aminoacylation |
| Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.