Search Results
Overview
| Uniprot ID | Q5I0K5 |
|---|---|
| Protein Name | Palmitoyl-protein thioesterase ABHD10, mitochondrial |
| Gene Name | Abhd10 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 83 | LSNMNGKKAVAIEEF |
Function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate
Protein Sequence
10
MAAWVPCRKW
20
GWAAVSFGRH
30
RGLIASLARK
40
PPWAWWLSAC
50
RQKTTLSFLK
60
RPELPSLAYK
70
RLKGKNPGII
80
FIPGYLSNMN
90
GKKAVAIEEF
100
CKSIGHAFIR
110
FDYSGVGSSD
120
GNLAECSVGK
130
WRKDVLSILD
140
DIAEGPQILV
150
GSSLGGWLML
160
HAAIARPEKV
170
IALIGIASAT
180
DGVVTQFHSL
190
PVEMQKEIEM
200
KGEWSLPSKY
210
NKEGYYSIPY
220
SFIKEAAHHC
230
LLHSPIPVTC
240
PVRLLHGMKD
250
EIVPWHRSLQ
260
VADRVVSPDV
270
DVILRKHSDH
280
RMKETADIHL
290
LICTIDDLID
KLSTVTH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| Molecular Function | GO:0102390 | mycophenolic acid acyl-glucuronide esterase activity |
| Molecular Function | GO:0008474 | palmitoyl-(protein) hydrolase activity |
| Biological Process | GO:0002084 | protein depalmitoylation |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.