Search Results
Overview
| Uniprot ID | Q5IRJ6 |
|---|---|
| Protein Name | Proton-coupled zinc antiporter SLC30A9, mitochondrial |
| Gene Name | Slc30a9 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 478 | VRAIHDVKATDLGLG |
| 486 | ATDLGLGKVRFKAEV |
Function
Acts as a zinc transporter involved in intracellular zinc homeostasis (By similarity). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes (PubMed:15988012). Plays a role in transcriptional activation of Wnt-responsive genes (PubMed:17344318)
Protein Sequence
10
MFPGLAAAAA
20
AHRCSWAALC
30
RLGGGRAATR
40
GRSQGWKNVM
50
TFESFTYVVP
60
DIHPHLSIIN
70
QVKLYSTNVQ
80
KGGQGSQTPK
90
ADKVPSLTQT
100
VENIGAELKA
110
PLKQDPLQVR
120
VKAVLKKRDY
130
GSKYTKNNFI
140
TGVRAINEFC
150
LKSSDLEQLR
160
KIRRRSPHDD
170
TESFTVFLRS
180
DVEAKALEVW
190
GSLEALAREK
200
KLRKEAEIEY
210
RERLFRNQRI
220
LREYGDFLGN
230
TKPRSRAVSV
240
FLKGPGKVVM
250
VAICINGLNC
260
FFKFLAWIYT
270
GSASMFSEAI
280
HSLSDTCNQG
290
LLALGISKSV
300
QTPDPSHPYG
310
FSNMRYISSL
320
ISGVGIFMMG
330
AGLSWYHGIM
340
GLLHPQPMES
350
LLWAYCILAG
360
SLVSEGATLL
370
VAINELRRSA
380
QAKGTTFYKY
390
VMESRDPSTN
400
VILLEDTAAV
410
LGVIIAATCM
420
GLTSITGNPL
430
YDSLGSLGVG
440
TLLGVVSAFL
450
IYTNTEALLG
460
RSIQPEQVQR
470
LTELLESDPS
480
VRAIHDVKAT
490
DLGLGKVRFK
500
AEVDFDGRVV
510
TRSYLEKQDF
520
DQMMQEIQEV
530
KTPEQLEAFM
540
LKHGENIIDT
550
LGAEVDRLEK
560
ELKKRNPEVR
HVDLEIL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0015297 | antiporter activity |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0016922 | nuclear receptor binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0005385 | zinc ion transmembrane transporter activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006882 | intracellular zinc ion homeostasis |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010821 | regulation of mitochondrion organization |
| Biological Process | GO:0006829 | zinc ion transport |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.