Search Results
Overview
| Uniprot ID | Q5JPH6 |
|---|---|
| Protein Name | Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial |
| Gene Name | EARS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 152 | QRLELLKKEALRNHQ |
Function
Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation (PubMed:19805282). Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln) (PubMed:19805282). In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity (PubMed:19805282)
Protein Sequence
10
MAALLRRLLQ
20
RERPSAASGR
30
PVGRREANLG
40
TDAGVAVRVR
50
FAPSPTGFLH
60
LGGLRTALYN
70
YIFAKKYQGS
80
FILRLEDTDQ
90
TRVVPGAAEN
100
IEDMLEWAGI
110
PPDESPRRGG
120
PAGPYQQSQR
130
LELYAQATEA
140
LLKTGAAYPC
150
FCSPQRLELL
160
KKEALRNHQT
170
PRYDNRCRNM
180
SQEQVAQKLA
190
KDPKPAIRFR
200
LEQVVPAFQD
210
LVYGWNRHEV
220
ASVEGDPVIM
230
KSDGFPTYHL
240
ACVVDDHHMG
250
ISHVLRGSEW
260
LVSTAKHLLL
270
YQALGWQPPH
280
FAHLPLLLNR
290
DGSKLSKRQG
300
DVFLEHFAAD
310
GFLPDSLLDI
320
ITNCGSGFAE
330
NQMGRTLPEL
340
ITQFNLTQVT
350
CHSALLDLEK
360
LPEFNRLHLQ
370
RLVSNESQRR
380
QLVGKLQVLV
390
EEAFGCQLQN
400
RDVLNPVYVE
410
RILLLRQGHI
420
CRLQDLVSPV
430
YSYLWTRPAV
440
GRAQLDAISE
450
KVDVIAKRVL
460
GLLERSSMSL
470
TQDMLNGELK
480
KLSEGLEGTK
490
YSNVMKLLRM
500
ALSGQQQGPP
510
VAEMMLALGP
520
KEVRERIQKV
VSS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004818 | glutamate-tRNA ligase activity |
| Molecular Function | GO:0050561 | glutamate-tRNA(Gln) ligase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006424 | glutamyl-tRNA aminoacylation |
| Biological Process | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.