Search Results
Overview
| Uniprot ID | Q5JQC9 |
|---|---|
| Protein Name | A-kinase anchor protein 4 |
| Gene Name | AKAP4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | STSTCKHKVGDTEGE |
| 183 | RLEMTAAKNTNNNQS |
| 234 | LVIQMAHKEIKEKLE |
| 237 | QMAHKEIKEKLEGKS |
| 245 | EKLEGKSKCLHHSIC |
| 25 | RSHRGVCKVDLYNPE |
| 258 | ICPSPGNKERISPRT |
| 299 | ESREGGQKSFLYSEL |
| 309 | LYSELSNKSKSGDKQ |
| 315 | NKSKSGDKQMSQRES |
| 323 | QMSQRESKEFADSIS |
| 353 | VSLMKTLKVHSSGKP |
| 359 | LKVHSSGKPIPASVV |
| 368 | IPASVVLKRVLLRHT |
| 376 | RVLLRHTKEIVSDLI |
| 40 | GQQDQDRKVICFVDV |
| 428 | DIMEAMLKRLVSALI |
| 439 | SALIGEEKETKSQSL |
| 442 | IGEEKETKSQSLSYA |
| 452 | SLSYASLKAGSHDPK |
| 471 | SLEFSTMKAEMKERD |
| 483 | ERDKGKMKSDPCKSL |
| 488 | KMKSDPCKSLTSAEK |
| 495 | KSLTSAEKVGEHILK |
| 502 | KVGEHILKEGLTIWN |
| 511 | GLTIWNQKQGNSCKV |
| 517 | QKQGNSCKVATKACS |
| 521 | NSCKVATKACSNKDE |
| 532 | NKDEKGEKINASTDS |
| 542 | ASTDSLAKDLIVSAL |
| 561 | YHLTQQTKGKDTCEE |
| 563 | LTQQTKGKDTCEEDC |
| 586 | AQSTQYEKCGGGQSA |
| 599 | SAKALSVKQLESHRA |
| 614 | PGPSTCQKENQHLDS |
| 623 | NQHLDSQKMDMSNIV |
| 644 | LLNENPFKCEDPCEG |
| 654 | DPCEGENKCSEPRAS |
| 662 | CSEPRASKAASMSNR |
| 672 | SMSNRSDKAEEQCQE |
| 733 | EQAASANKPNFRGTR |
| 814 | VSAKAAEKGYSVGGL |
| 83 | EKEIIVIKDTEKKDQ |
| 830 | QEVMKFAKERQPDEA |
| 840 | QPDEAVGKVARKQLL |
| 88 | VIKDTEKKDQSKTEG |
| 92 | TEKKDQSKTEGSVCL |
Function
Major structural component of sperm fibrous sheath (PubMed:9822690). Plays a role in sperm motility (PubMed:34415320, PubMed:9822690)
Protein Sequence
10
MMAYSDTTMM
20
SDDIDWLRSH
30
RGVCKVDLYN
40
PEGQQDQDRK
50
VICFVDVSTL
60
NVEDKDYKDA
70
ASSSSEGNLN
80
LGSLEEKEII
90
VIKDTEKKDQ
100
SKTEGSVCLF
110
KQAPSDPVSV
120
LNWLLSDLQK
130
YALGFQHALS
140
PSTSTCKHKV
150
GDTEGEYHRA
160
SSENCYSVYA
170
DQVNIDYLMN
180
RPQNLRLEMT
190
AAKNTNNNQS
200
PSAPPAKPPS
210
TQRAVISPDG
220
ECSIDDLSFY
230
VNRLSSLVIQ
240
MAHKEIKEKL
250
EGKSKCLHHS
260
ICPSPGNKER
270
ISPRTPASKI
280
ASEMAYEAVE
290
LTAAEMRGTG
300
EESREGGQKS
310
FLYSELSNKS
320
KSGDKQMSQR
330
ESKEFADSIS
340
KGLMVYANQV
350
ASDMMVSLMK
360
TLKVHSSGKP
370
IPASVVLKRV
380
LLRHTKEIVS
390
DLIDSCMKNL
400
HNITGVLMTD
410
SDFVSAVKRN
420
LFNQWKQNAT
430
DIMEAMLKRL
440
VSALIGEEKE
450
TKSQSLSYAS
460
LKAGSHDPKC
470
RNQSLEFSTM
480
KAEMKERDKG
490
KMKSDPCKSL
500
TSAEKVGEHI
510
LKEGLTIWNQ
520
KQGNSCKVAT
530
KACSNKDEKG
540
EKINASTDSL
550
AKDLIVSALK
560
LIQYHLTQQT
570
KGKDTCEEDC
580
PGSTMGYMAQ
590
STQYEKCGGG
600
QSAKALSVKQ
610
LESHRAPGPS
620
TCQKENQHLD
630
SQKMDMSNIV
640
LMLIQKLLNE
650
NPFKCEDPCE
660
GENKCSEPRA
670
SKAASMSNRS
680
DKAEEQCQEH
690
QELDCTSGMK
700
QANGQFIDKL
710
VESVMKLCLI
720
MAKYSNDGAA
730
LAELEEQAAS
740
ANKPNFRGTR
750
CIHSGAMPQN
760
YQDSLGHEVI
770
VNNQCSTNSL
780
QKQLQAVLQW
790
IAASQFNVPM
800
LYFMGDKDGQ
810
LEKLPQVSAK
820
AAEKGYSVGG
830
LLQEVMKFAK
840
ERQPDEAVGK
850
VARKQLLDWL
LANL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0008104 | intracellular protein localization |
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0097229 | sperm end piece |
| Cellular Component | GO:0035686 | sperm fibrous sheath |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0120212 | sperm head-tail coupling apparatus |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0097228 | sperm principal piece |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051018 | protein kinase A binding |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007338 | single fertilization |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.