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Overview

Uniprot IDQ5JSL3
Protein NameDedicator of cytokinesis protein 11
Gene NameDOCK11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 KFTKRLSKPGTAAEL

Function

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957)

Protein Sequence

10 MAEVRKFTKR 20 LSKPGTAAEL 30 RQSVSEAVRG 40 SVVLEKAKVV 50 EPLDYENVIA 60 QRKTQIYSDP 70 LRDLLMFPME 80 DISISVIGRQ 90 RRTVQSTVPE 100 DAEKRAQSLF 110 VKECIKTYST 120 DWHVVNYKYE 130 DFSGDFRMLP 140 CKSLRPEKIP 150 NHVFEIDEDC 160 EKDEDSSSLC 170 SQKGGVIKQG 180 WLHKANVNST 190 ITVTMKVFKR 200 RYFYLTQLPD 210 GSYILNSYKD 220 EKNSKESKGC 230 IYLDACIDVV 240 QCPKMRRHAF 250 ELKMLDKYSH 260 YLAAETEQEM 270 EEWLITLKKI 280 IQINTDSLVQ 290 EKKETVETAQ 300 DDETSSQGKA 310 ENIMASLERS 320 MHPELMKYGR 330 ETEQLNKLSR 340 GDGRQNLFSF 350 DSEVQRLDFS 360 GIEPDIKPFE 370 EKCNKRFLVN 380 CHDLTFNILG 390 QIGDNAKGPP 400 TNVEPFFINL 410 ALFDVKNNCK 420 ISADFHVDLN 430 PPSVREMLWG 440 SSTQLASDGS 450 PKGSSPESYI 460 HGIAESQLRY 470 IQQGIFSVTN 480 PHPEIFLVAR 490 IEKVLQGNIT 500 HCAEPYIKNS 510 DPVKTAQKVH 520 RTAKQVCSRL 530 GQYRMPFAWA 540 ARPIFKDTQG 550 SLDLDGRFSP 560 LYKQDSSKLS 570 SEDILKLLSE 580 YKKPEKTKLQ 590 IIPGQLNITV 600 ECVPVDLSNC 610 ITSSYVPLKP 620 FEKNCQNITV 630 EVEEFVPEMT 640 KYCYPFTIYK 650 NHLYVYPLQL 660 KYDSQKTFAK 670 ARNIAVCVEF 680 RDSDESDASA 690 LKCIYGKPAG 700 SVFTTNAYAV 710 VSHHNQNPEF 720 YDEIKIELPI 730 HLHQKHHLLF 740 TFYHVSCEIN 750 TKGTTKKQDT 760 VETPVGFAWV 770 PLLKDGRIIT 780 FEQQLPVSAN 790 LPPGYLNLND 800 AESRRQCNVD 810 IKWVDGAKPL 820 LKIKSHLEST 830 IYTQDLHVHK 840 FFHHCQLIQS 850 GSKEVPGELI 860 KYLKCLHAME 870 IQVMIQFLPV 880 ILMQLFRVLT 890 NMTHEDDVPI 900 NCTMVLLHIV 910 SKCHEEGLDS 920 YLRSFIKYSF 930 RPEKPSAPQA 940 QLIHETLATT 950 MIAILKQSAD 960 FLSINKLLKY 970 SWFFFEIIAK 980 SMATYLLEEN 990 KIKLPRGQRF 1000 PETYHHVLHS 1010 LLLAIIPHVT 1020 IRYAEIPDES 1030 RNVNYSLASF 1040 LKRCLTLMDR 1050 GFIFNLINDY 1060 ISGFSPKDPK 1070 VLAEYKFEFL 1080 QTICNHEHYI 1090 PLNLPMAFAK 1100 PKLQRVQDSN 1110 LEYSLSDEYC 1120 KHHFLVGLLL 1130 RETSIALQDN 1140 YEIRYTAISV 1150 IKNLLIKHAF 1160 DTRYQHKNQQ 1170 AKIAQLYLPF 1180 VGLLLENIQR 1190 LAGRDTLYSC 1200 AAMPNSASRD 1210 EFPCGFTSPA 1220 NRGSLSTDKD 1230 TAYGSFQNGH 1240 GIKREDSRGS 1250 LIPEGATGFP 1260 DQGNTGENTR 1270 QSSTRSSVSQ 1280 YNRLDQYEIR 1290 SLLMCYLYIV 1300 KMISEDTLLT 1310 YWNKVSPQEL 1320 INILILLEVC 1330 LFHFRYMGKR 1340 NIARVHDAWL 1350 SKHFGIDRKS 1360 QTMPALRNRS 1370 GVMQARLQHL 1380 SSLESSFTLN 1390 HSSTTTEADI 1400 FHQALLEGNT 1410 ATEVSLTVLD 1420 TISFFTQCFK 1430 TQLLNNDGHN 1440 PLMKKVFDIH 1450 LAFLKNGQSE 1460 VSLKHVFASL 1470 RAFISKFPSA 1480 FFKGRVNMCA 1490 AFCYEVLKCC 1500 TSKISSTRNE 1510 ASALLYLLMR 1520 NNFEYTKRKT 1530 FLRTHLQIII 1540 AVSQLIADVA 1550 LSGGSRFQES 1560 LFIINNFANS 1570 DRPMKATAFP 1580 AEVKDLTKRI 1590 RTVLMATAQM 1600 KEHEKDPEML 1610 IDLQYSLAKS 1620 YASTPELRKT 1630 WLDSMAKIHV 1640 KNGDFSEAAM 1650 CYVHVAALVA 1660 EFLHRKKLFP 1670 NGCSAFKKIT 1680 PNIDEEGAMK 1690 EDAGMMDVHY 1700 SEEVLLELLE 1710 QCVDGLWKAE 1720 RYEIISEISK 1730 LIVPIYEKRR 1740 EFEKLTQVYR 1750 TLHGAYTKIL 1760 EVMHTKKRLL 1770 GTFFRVAFYG 1780 QSFFEEEDGK 1790 EYIYKEPKLT 1800 GLSEISLRLV 1810 KLYGEKFGTE 1820 NVKIIQDSDK 1830 VNAKELDPKY 1840 AHIQVTYVKP 1850 YFDDKELTER 1860 KTEFERNHNI 1870 SRFVFEAPYT 1880 LSGKKQGCIE 1890 EQCKRRTILT 1900 TSNSFPYVKK 1910 RIPINCEQQI 1920 NLKPIDVATD 1930 EIKDKTAELQ 1940 KLCSSTDVDM 1950 IQLQLKLQGC 1960 VSVQVNAGPL 1970 AYARAFLNDS 1980 QASKYPPKKV 1990 SELKDMFRKF 2000 IQACSIALEL 2010 NERLIKEDQV 2020 EYHEGLKSNF 2030 RDMVKELSDI 2040 IHEQILQEDT 2050 MHSPWMSNTL 2060 HVFCAISGTS 2070 SDRGYGSPRY AEV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0001782 B cell homeostasis
Biological Process GO:0002315 marginal zone B cell differentiation
Biological Process GO:0051491 positive regulation of filopodium assembly
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

PMID: N/A