Search Results

Overview

Uniprot IDQ5JTH9
Protein NameRRP12-like protein
Gene NameRRP12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1226 IHRPVAKKAMPGAEY
1268 LNRRKKMKLQGQFKG
14 LPSGVSAKLKRWKKG
6 **MGRSGKLPSGVSA

Function

Participates in the nucleoplasmic stage of pre-40S ribosomal subunit assembly, functioning as a scaffold for assembly factors and preparing pre-40S particles for export from the nucleus to the cytoplasm

Protein Sequence

10 MGRSGKLPSG 20 VSAKLKRWKK 30 GHSSDSNPAI 40 CRHRQAARSR 50 FFSRPSGRSD 60 LTVDAVKLHN 70 ELQSGSLRLG 80 KSEAPETPME 90 EEAELVLTEK 100 SSGTFLSGLS 110 DCTNVTFSKV 120 QRFWESNSAA 130 HKEICAVLAA 140 VTEVIRSQGG 150 KETETEYFAA 160 LMTTMEAVES 170 PESLAAVAYL 180 LNLVLKRVPS 190 PVLIKKFSDT 200 SKAFMDIMSA 210 QASSGSTSVL 220 RWVLSCLATL 230 LRKQDLEAWG 240 YPVTLQVYHG 250 LLSFTVHPKP 260 KIRKAAQHGV 270 CSVLKGSEFM 280 FEKAPAHHPA 290 AISTAKFCIQ 300 EIEKSGGSKE 310 ATTTLHMLTL 320 LKDLLPCFPE 330 GLVKSCSETL 340 LRVMTLSHVL 350 VTACAMQAFH 360 SLFHARPGLS 370 TLSAELNAQI 380 ITALYDYVPS 390 ENDLQPLLAW 400 LKVMEKAHIN 410 LVRLQWDLGL 420 GHLPRFFGTA 430 VTCLLSPHSQ 440 VLTAATQSLK 450 EILKECVAPH 460 MADIGSVTSS 470 ASGPAQSVAK 480 MFRAVEEGLT 490 YKFHAAWSSV 500 LQLLCVFFEA 510 CGRQAHPVMR 520 KCLQSLCDLR 530 LSPHFPHTAA 540 LDQAVGAAVT 550 SMGPEVVLQA 560 VPLEIDGSEE 570 TLDFPRSWLL 580 PVIRDHVQET 590 RLGFFTTYFL 600 PLANTLKSKA 610 MDLAQAGSTV 620 ESKIYDTLQW 630 QMWTLLPGFC 640 TRPTDVAISF 650 KGLARTLGMA 660 ISERPDLRVT 670 VCQALRTLIT 680 KGCQAEADRA 690 EVSRFAKNFL 700 PILFNLYGQP 710 VAAGDTPAPR 720 RAVLETIRTY 730 LTITDTQLVN 740 SLLEKASEKV 750 LDPASSDFTR 760 LSVLDLVVAL 770 APCADEAAIS 780 KLYSTIRPYL 790 ESKAHGVQKK 800 AYRVLEEVCA 810 SPQGPGALFV 820 QSHLEDLKKT 830 LLDSLRSTSS 840 PAKRPRLKCL 850 LHIVRKLSAE 860 HKEFITALIP 870 EVILCTKEVS 880 VGARKNAFAL 890 LVEMGHAFLR 900 FGSNQEEALQ 910 CYLVLIYPGL 920 VGAVTMVSCS 930 ILALTHLLFE 940 FKGLMGTSTV 950 EQLLENVCLL 960 LASRTRDVVK 970 SALGFIKVAV 980 TVMDVAHLAK 990 HVQLVMEAIG 1000 KLSDDMRRHF 1010 RMKLRNLFTK 1020 FIRKFGFELV 1030 KRLLPEEYHR 1040 VLVNIRKAEA 1050 RAKRHRALSQ 1060 AAVEEEEEEE 1070 EEEEPAQGKG 1080 DSIEEILADS 1090 EDEEDNEEEE 1100 RSRGKEQRKL 1110 ARQRSRAWLK 1120 EGGGDEPLNF 1130 LDPKVAQRVL 1140 ATQPGPGRGR 1150 KKDHGFKVSA 1160 DGRLIIREEA 1170 DGNKMEEEEG 1180 AKGEDEEMAD 1190 PMEDVIIRNK 1200 KHQKLKHQKE 1210 AEEEELEIPP 1220 QYQAGGSGIH 1230 RPVAKKAMPG 1240 AEYKAKKAKG 1250 DVKKKGRPDP 1260 YAYIPLNRSK 1270 LNRRKKMKLQ 1280 GQFKGLVKAA 1290 RRGSQVGHKN RRKDRRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0003723 RNA binding

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.