Overview
| Uniprot ID | Q5JVF3 |
|---|
| Protein Name | PCI domain-containing protein 2 |
|---|
| Gene Name | PCID2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 133 |
LVKKGKSKVGDMLEK |
Function
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:22307388). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (PubMed:24896180). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity)
Protein Sequence
10
MAHITINQYL
20
QQVYEAIDSR
30
DGASCAELVS
40
FKHPHVANPR
50
LQMASPEEKC
60
QQVLEPPYDE
70
MFAAHLRCTY
80
AVGNHDFIEA
90
YKCQTVIVQS
100
FLRAFQAHKE
110
ENWALPVMYA
120
VALDLRVFAN
130
NADQQLVKKG
140
KSKVGDMLEK
150
AAELLMSCFR
160
VCASDTRAGI
170
EDSKKWGMLF
180
LVNQLFKIYF
190
KINKLHLCKP
200
LIRAIDSSNL
210
KDDYSTAQRV
220
TYKYYVGRKA
230
MFDSDFKQAE
240
EYLSFAFEHC
250
HRSSQKNKRM
260
ILIYLLPVKM
270
LLGHMPTVEL
280
LKKYHLMQFA
290
EVTRAVSEGN
300
LLLLHEALAK
310
HEAFFIRCGI
320
FLILEKLKII
330
TYRNLFKKVY
340
LLLKTHQLSL
350
DAFLVALKFM
360
QVEDVDIDEV
370
QCILANLIYM
380
GHVKGYISHQ
390
HQKLVVSKQN
PFPPLSTVC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0044615 |
nuclear pore nuclear basket |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0070390 |
transcription export complex 2 |
| Molecular Function |
GO:0003690 |
double-stranded DNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006406 |
mRNA export from nucleus |
| Biological Process |
GO:0045814 |
negative regulation of gene expression, epigenetic |
| Biological Process |
GO:1905457 |
negative regulation of lymphoid progenitor cell differentiation |
| Biological Process |
GO:0016973 |
poly(A)+ mRNA export from nucleus |
| Biological Process |
GO:0045579 |
positive regulation of B cell differentiation |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0000973 |
post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0048536 |
spleen development |
| Biological Process |
GO:0006368 |
transcription elongation by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.