Overview
| Uniprot ID | Q5JVS0 |
|---|
| Protein Name | Intracellular hyaluronan-binding protein 4 |
|---|
| Gene Name | HABP4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 321 |
PESTVPSKAVVIHKS |
Function
Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity)
Protein Sequence
10
MKGALGSPVA
20
AAGAAMQESF
30
GCVVANRFHQ
40
LLDDESDPFD
50
ILREAERRRQ
60
QQLQRKRRDE
70
AAAAAGAGPR
80
GGRSPAGASG
90
HRAGAGGRRE
100
SQKERKSLPA
110
PVAQRPDSPG
120
GGLQAPGQKR
130
TPRRGEQQGW
140
NDSRGPEGML
150
ERAERRSYRE
160
YRPYETERQA
170
DFTAEKFPDE
180
KPGDRFDRDR
190
PLRGRGGPRG
200
GMRGRGRGGP
210
GNRVFDAFDQ
220
RGKREFERYG
230
GNDKIAVRTE
240
DNMGGCGVRT
250
WGSGKDTSDV
260
EPTAPMEEPT
270
VVEESQGTPE
280
EESPAKVPEL
290
EVEEETQVQE
300
MTLDEWKNLQ
310
EQTRPKPEFN
320
IRKPESTVPS
330
KAVVIHKSKY
340
RDDMVKDDYE
350
DDSHVFRKPA
360
NDITSQLEIN
370
FGNLPRPGRG
380
ARGGTRGGRG
390
RIRRAENYGP
400
RAEVVMQDVA
410
PNPDDPEDFP
ALS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015030 |
Cajal body |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0010494 |
cytoplasmic stress granule |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0097504 |
Gemini of Cajal bodies |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0030017 |
sarcomere |
| Cellular Component |
GO:0016528 |
sarcoplasm |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0032183 |
SUMO binding |
| Molecular Function |
GO:0061770 |
translation elongation factor binding |
| Biological Process |
GO:0071260 |
cellular response to mechanical stimulus |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0030578 |
PML body organization |
| Biological Process |
GO:0033120 |
positive regulation of RNA splicing |
| Biological Process |
GO:0045948 |
positive regulation of translational initiation |
| Biological Process |
GO:0141014 |
ribosome hibernation |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
PMID: N/A