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Overview

Uniprot IDQ5JWF2
Protein NameGuanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Gene NameGNAS
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
696 LGAGESGKSTIVKQM

Function

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms

Protein Sequence

10 MGVRNCLYGN 20 NMSGQRDIPP 30 EIGEQPEQPP 40 LEAPGAAAPG 50 AGPSPAEEME 60 TEPPHNEPIP 70 VENDGEACGP 80 PEVSRPNFQV 90 LNPAFREAGA 100 HGSYSPPPEE 110 AMPFEAEQPS 120 LGGFWPTLEQ 130 PGFPSGVHAG 140 LEAFGPALME 150 PGAFSGARPG 160 LGGYSPPPEE 170 AMPFEFDQPA 180 QRGCSQLLLQ 190 VPDLAPGGPG 200 AAGVPGAPPE 210 EPQALRPAKA 220 GSRGGYSPPP 230 EETMPFELDG 240 EGFGDDSPPP 250 GLSRVIAQVD 260 GSSQFAAVAA 270 SSAVRLTPAA 280 NAPPLWVPGA 290 IGSPSQEAVR 300 PPSNFTGSSP 310 WMEISGPPFE 320 IGSAPAGVDD 330 TPVNMDSPPI 340 ALDGPPIKVS 350 GAPDKRERAE 360 RPPVEEEAAE 370 MEGAADAAEG 380 GKVPSPGYGS 390 PAAGAASADT 400 AARAAPAAPA 410 DPDSGATPED 420 PDSGTAPADP 430 DSGAFAADPD 440 SGAAPAAPAD 450 PDSGAAPDAP 460 ADPDSGAAPD 470 APADPDAGAA 480 PEAPAAPAAA 490 ETRAAHVAPA 500 APDAGAPTAP 510 AASATRAAQV 520 RRAASAAPAS 530 GARRKIHLRP 540 PSPEIQAADP 550 PTPRPTRASA 560 WRGKSESSRG 570 RRVYYDEGVA 580 SSDDDSSGDE 590 SDDGTSGCLR 600 WFQHRRNRRR 610 RKPQRNLLRN 620 FLVQAFGGCF 630 GRSESPQPKA 640 SRSLKVKKVP 650 LAEKRRQMRK 660 EALEKRAQKR 670 AEKKRSKLID 680 KQLQDEKMGY 690 MCTHRLLLLG 700 AGESGKSTIV 710 KQMRILHVNG 720 FNGEGGEEDP 730 QAARSNSDGE 740 KATKVQDIKN 750 NLKEAIETIV 760 AAMSNLVPPV 770 ELANPENQFR 780 VDYILSVMNV 790 PDFDFPPEFY 800 EHAKALWEDE 810 GVRACYERSN 820 EYQLIDCAQY 830 FLDKIDVIKQ 840 ADYVPSDQDL 850 LRCRVLTSGI 860 FETKFQVDKV 870 NFHMFDVGGQ 880 RDERRKWIQC 890 FNDVTAIIFV 900 VASSSYNMVI 910 REDNQTNRLQ 920 EALNLFKSIW 930 NNRWLRTISV 940 ILFLNKQDLL 950 AEKVLAGKSK 960 IEDYFPEFAR 970 YTTPEDATPE 980 PGEDPRVTRA 990 KYFIRDEFLR 1000 ISTASGDGRH 1010 YCYPHFTCAV 1020 DTENIRRVFN 1030 DCRDIIQRMH LRQYELL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Biological Process GO:0060348 bone development
Biological Process GO:0048589 developmental growth
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0007606 sensory perception of chemical stimulus
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005834 heterotrimeric G-protein complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0010856 adenylate cyclase activator activity
Molecular Function GO:0031698 beta-2 adrenergic receptor binding
Molecular Function GO:0051430 corticotropin-releasing hormone receptor 1 binding
Molecular Function GO:0031748 D1 dopamine receptor binding
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0031683 G-protein beta/gamma-subunit complex binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0005159 insulin-like growth factor receptor binding
Molecular Function GO:0035255 ionotropic glutamate receptor binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0031852 mu-type opioid receptor binding
Biological Process GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.