Search Results
Overview
| Uniprot ID | Q5K4L6 |
|---|---|
| Protein Name | Long-chain fatty acid transport protein 3 |
| Gene Name | SLC27A3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 635 | LATTETFKQQKVRMA |
Function
Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:23936004). Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes (By similarity)
Protein Sequence
10
MAALLLLPLL
20
LLLPLLLLKL
30
HLWPQLRWLP
40
ADLAFAVRAL
50
CCKRALRARA
60
LAAAAADPEG
70
PEGGCSLAWR
80
LAELAQQRAA
90
HTFLIHGSRR
100
FSYSEAERES
110
NRAARAFLRA
120
LGWDWGPDGG
130
DSGEGSAGEG
140
ERAAPGAGDA
150
AAGSGAEFAG
160
GDGAARGGGA
170
AAPLSPGATV
180
ALLLPAGPEF
190
LWLWFGLAKA
200
GLRTAFVPTA
210
LRRGPLLHCL
220
RSCGARALVL
230
APEFLESLEP
240
DLPALRAMGL
250
HLWAAGPGTH
260
PAGISDLLAE
270
VSAEVDGPVP
280
GYLSSPQSIT
290
DTCLYIFTSG
300
TTGLPKAARI
310
SHLKILQCQG
320
FYQLCGVHQE
330
DVIYLALPLY
340
HMSGSLLGIV
350
GCMGIGATVV
360
LKSKFSAGQF
370
WEDCQQHRVT
380
VFQYIGELCR
390
YLVNQPPSKA
400
ERGHKVRLAV
410
GSGLRPDTWE
420
RFVRRFGPLQ
430
VLETYGLTEG
440
NVATINYTGQ
450
RGAVGRASWL
460
YKHIFPFSLI
470
RYDVTTGEPI
480
RDPQGHCMAT
490
SPGEPGLLVA
500
PVSQQSPFLG
510
YAGGPELAQG
520
KLLKDVFRPG
530
DVFFNTGDLL
540
VCDDQGFLRF
550
HDRTGDTFRW
560
KGENVATTEV
570
AEVFEALDFL
580
QEVNVYGVTV
590
PGHEGRAGMA
600
ALVLRPPHAL
610
DLMQLYTHVS
620
ENLPPYARPR
630
FLRLQESLAT
640
TETFKQQKVR
650
MANEGFDPST
660
LSDPLYVLDQ
670
AVGAYLPLTT
680
ARYSALLAGN
LRI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004467 | long-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0031957 | very long-chain fatty acid-CoA ligase activity |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.