Search Results

Overview

Uniprot IDQ5M7U6
Protein NameActin-related protein 2
Gene NameActr2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
118 EPPMNPTKNREKIVE
219 TVRMIKEKLCYVGYN
322 SRLERELKQLYLERV
331 LYLERVLKGDVEKLS
368 LADIMKDKDNFWMTR
381 TRQEYQEKGVRVLEK
388 KGVRVLEKLGVTVR*
46 PIIRSTTKVGNIEIK
7 *MDSQGRKVVVCDNG

Function

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)

Protein Sequence

10 MDSQGRKVVV 20 CDNGTGFVKC 30 GYAGSNFPEH 40 IFPALVGRPI 50 IRSTTKVGNI 60 EIKDLMVGDE 70 ASELRSMLEV 80 NYPMENGIVR 90 NWDDMKHLWD 100 YTFGPEKLNI 110 DTRSCKILLT 120 EPPMNPTKNR 130 EKIVEVMFET 140 YQFSGVYVAI 150 QAVLTLYAQG 160 LLTGVVVDSG 170 DGVTHICPVY 180 EGFSLPHLTR 190 RLDIAGRDIT 200 RYLIKLLLLR 210 GYAFNHSADF 220 ETVRMIKEKL 230 CYVGYNIEQE 240 QKLALETTVL 250 VESYTLPDGR 260 IIKVGGERFE 270 APEALFQPHL 280 INVEGVGVAE 290 LLFNTIQAAD 300 IDTRSEFYKH 310 IVLSGGSTMY 320 PGLPSRLERE 330 LKQLYLERVL 340 KGDVEKLSKF 350 KIRIEDPPRR 360 KHMVFLGGAV 370 LADIMKDKDN 380 FWMTRQEYQE 390 KGVRVLEKLG VTVR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030478 actin cap
Cellular Component GO:0005885 Arp2/3 protein complex
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005634 nucleus
Cellular Component GO:0061825 podosome core
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0034314 Arp2/3 complex-mediated actin nucleation
Biological Process GO:0008306 associative learning
Biological Process GO:0008356 asymmetric cell division
Biological Process GO:0035984 cellular response to trichostatin A
Biological Process GO:0071346 cellular response to type II interferon
Biological Process GO:0060271 cilium assembly
Biological Process GO:0016482 cytosolic transport
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0016344 meiotic chromosome movement towards spindle pole
Biological Process GO:0033206 meiotic cytokinesis
Biological Process GO:0061003 positive regulation of dendritic spine morphogenesis
Biological Process GO:1905168 positive regulation of double-strand break repair via homologous recombination
Biological Process GO:0010592 positive regulation of lamellipodium assembly
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045471 response to ethanol
Biological Process GO:0035902 response to immobilization stress
Biological Process GO:0051653 spindle localization

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.