Search Results
Overview
| Uniprot ID | Q5M7W7 |
|---|---|
| Protein Name | Probable proline--tRNA ligase, mitochondrial |
| Gene Name | Pars2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 382 | IPPKKGSKEAAATEI |
Function
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro)
Protein Sequence
10
MEGLLTRCRT
20
LSALATCSLR
30
HSRCIVRKCY
40
HCAPGRGQRL
50
VVSRMFQPQN
60
LREDQVLSLE
70
GRASDLTCKS
80
QRLMLQVGLI
90
LPASPGCYHL
100
MPYTVRAVEK
110
LVRVIDQEMQ
120
AIGGQKINMP
130
SLSPAELWRA
140
TGRWDLMGRE
150
LLRLKDRHGK
160
EYCLGPTHEE
170
AVTALVASQK
180
KLSYKQLPLL
190
LYQVTRKFRD
200
EPRPRFGLLR
210
GREFYMKDMY
220
TFDSSSEAAQ
230
ETYSLVCDAY
240
CRLFDRLGLR
250
WMKARADVGS
260
IGGTMSHEFQ
270
LPVDIGEDRL
280
VVCPSCHFSA
290
NTEIVDLSQK
300
ICPDCQGPLT
310
ETKGIEVGHT
320
FYLGTKYSSI
330
FNAHFTNAHG
340
ESLLAEMGCY
350
GLGVTRILAA
360
AIEVLSTEDC
370
IRWPSLLAPY
380
QVCIIPPKKG
390
SKEAAATEIV
400
ERLYDDVTEA
410
LPQLRGEVLL
420
DDRTHLTIGN
430
RLKDANKLGY
440
PFVIIASKRA
450
LEDPAHFEVW
460
SQNTGEVVFL
470
TKEGVMELLT
GVHVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004827 | proline-tRNA ligase activity |
| Biological Process | GO:0006433 | prolyl-tRNA aminoacylation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.