Overview
| Uniprot ID | Q5M865 |
|---|
| Protein Name | PAXIP1-associated glutamate-rich protein 1 |
|---|
| Gene Name | Pagr1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 202 |
KREARLDKVLSDMKR |
Function
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent
Protein Sequence
10
MSLALGHGTI
20
AGSTAAPLSE
30
EGEVTSGLQA
40
LAVEDTGGPS
50
VSASKAEEEG
60
KGSQEEAGRE
70
ASRAEEALEA
80
SSAVSDERAE
90
GESEDWCVPC
100
SDEEVELPAN
110
GQSWMPPPSE
120
IQRLYELLAT
130
QGTLELQAEI
140
LPRRPPTPEA
150
QSEEERSDEE
160
PEAKEEEEEK
170
PHMPTEFDFD
180
DEPVTPKDSL
190
IDRRRTPGSS
200
ARSQKREARL
210
DKVLSDMKRH
220
KKLEEQILRT
230
GRDLFSLDSE
240
GPSPASPPLR
250
SSGNSLFPRQ
RKY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035097 |
histone methyltransferase complex |
| Cellular Component |
GO:0044666 |
MLL3/4 complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0030331 |
nuclear estrogen receptor binding |
| Biological Process |
GO:0060717 |
chorion development |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0006310 |
DNA recombination |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:1902808 |
positive regulation of cell cycle G1/S phase transition |
| Biological Process |
GO:0033148 |
positive regulation of intracellular estrogen receptor signaling pathway |
| Biological Process |
GO:0048304 |
positive regulation of isotype switching to IgG isotypes |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:1902749 |
regulation of cell cycle G2/M phase transition |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.