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Overview

Uniprot ID	Q5M9I5
Protein Name	Cytochrome b-c1 complex subunit 6, mitochondrial
Gene Name	Uqcrh
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
40	EHCEQLEKCVKARER
83	RDHCVAHKLFKSLK*

Function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c

Protein Sequence

10 MGLEDERKML 20 TGSGDPKEEE 30 EEELVDPLTT 40 VREHCEQLEK 50 CVKARERLES 60 CDRRVSSRSQ 70 TEEDCTEELF 80 DFLHARDHCV AHKLFKSLK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0045275	respiratory chain complex III
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0008121	quinol-cytochrome-c reductase activity
Biological Process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.