Search Results
Overview
| Uniprot ID | Q5MPA9 |
|---|---|
| Protein Name | Serine/threonine-protein kinase DCLK2 |
| Gene Name | Dclk2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | TLAVASAKSEVKESK |
| 301 | YSRASAAKYSGSRSP |
Function
Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity)
Protein Sequence
10
MASTRSIELE
20
HFEERDKRPR
30
PGSRRGAPSS
40
SGGSSISGPK
50
GNGLIPSPAH
60
SAHCSFYRTR
70
TLQALSSEKK
80
AKKARFYRNG
90
DRYFKGLVFA
100
ISSDRFRSFD
110
ALLIELTRSL
120
SDNVNLPQGV
130
RTIYTVDGSR
140
KVTSLDELLE
150
GESYVCASNE
160
PFRKVDYTKN
170
VNPNWSVNIK
180
GGTTRTLAVA
190
SAKSEVKESK
200
DFIKPKLVTV
210
IRSGVKPRKA
220
VRILLNKKTA
230
HSFEQVLTDI
240
TEAIKLDSGV
250
VKRLCTLDGK
260
QVTCLQDFFG
270
DDDVFIACGP
280
EKYRYAQDDF
290
VLDHSECRVL
300
KSSYSRASAA
310
KYSGSRSPGL
320
SRRSKSPASV
330
KRAGHSSAYS
340
TAKSPVNGTP
350
SSQLSTPKST
360
KSSSSSPTSP
370
GSFRGLKQIS
380
AQGRSSSNVN
390
GGPELDRCMS
400
PEGVNGNRCS
410
ESFTLLEKYR
420
IGKVIGDGNF
430
AVVKECMDRS
440
TGKEFALKII
450
DKAKCCGKEH
460
LIENEVSILR
470
RVKHPNIIML
480
VEEMETTTEL
490
FLVMELVKGG
500
DLFDAITSST
510
KYTERDGSAM
520
VYNLASALRY
530
LHGLSIVHRD
540
IKPENLLVCE
550
YPDGTKSLKL
560
GDFGLATVVE
570
GPLYTVCGTP
580
TYVAPEIIAE
590
TGYGLKVDVW
600
AAGVITYILL
610
CGFPPFRSEN
620
NLQEDLFDQI
630
LAGKLEFPAP
640
YWDNITDSAK
650
ELISQMLQVN
660
VEARCTAGEI
670
LSHPWVSDDA
680
SQENNMQAEV
690
TGKLKQHFNN
700
ALPKQNSTTT
710
GVSVIMNTAL
720
DKEGQVFCSK
730
HCRDSSKSSR
740
EQTSAREAPP
750
PPESPRPPGP
760
PATSGCDPAG
TWRRHRD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:1900181 | negative regulation of protein localization to nucleus |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0021860 | pyramidal neuron development |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.