Search Results
Overview
| Uniprot ID | Q5PPL2 |
|---|---|
| Protein Name | DCN1-like protein 5 |
| Gene Name | Dcun1d5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 23 | VAEDAGLKKCKISSY |
| 26 | DAGLKKCKISSYCRS |
| 8 | MPVKKKRKAPGVAAA |
Function
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth
Protein Sequence
10
MPVKKKRKAP
20
GVAAAVAEDA
30
GLKKCKISSY
40
CRSQPPARLI
50
SGEEDFSRKK
60
CLAWFYEYAG
70
PDEVVGPEGM
80
EKFCEDIGVE
90
PENIIMLVLA
100
WKLEAESMGF
110
FTKEEWLKGM
120
TSLQCDCTEK
130
LQSRFDFLRS
140
QLNDISSFKN
150
IYRYAFDFAR
160
DKDQRSLDID
170
TAKSMLALLL
180
GRTWPLFSVF
190
YQYLEQSKYR
200
VMNKDQWYNV
210
LEFSRTVHAD
220
LSNYDEDGAW
230
PVLLDEFVEW
QKIRQTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0000151 | ubiquitin ligase complex |
| Molecular Function | GO:0097602 | cullin family protein binding |
| Molecular Function | GO:0031624 | ubiquitin conjugating enzyme binding |
| Molecular Function | GO:0032182 | ubiquitin-like protein binding |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:2000436 | positive regulation of protein neddylation |
| Biological Process | GO:0045116 | protein neddylation |
| Biological Process | GO:0001558 | regulation of cell growth |
| Biological Process | GO:2000434 | regulation of protein neddylation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.