Search Results
Overview
| Uniprot ID | Q5PPN5 |
|---|---|
| Protein Name | Tubulin polymerization-promoting protein family member 3 |
| Gene Name | Tppp3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 130 | DRLTDTSKYTGSHKE |
| 16 | GLEESFRKFAIHGDP |
| 173 | NAGTYDAKVKK**** |
Function
Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0097427 | microtubule bundle |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0046697 | decidualization |
| Biological Process | GO:0007566 | embryo implantation |
| Biological Process | GO:0001578 | microtubule bundle formation |
| Biological Process | GO:0046785 | microtubule polymerization |
| Biological Process | GO:0032273 | positive regulation of protein polymerization |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.