Overview
| Uniprot ID | Q5PQK2 |
|---|
| Protein Name | RNA-binding protein FUS |
|---|
| Gene Name | Fus |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 305 |
IGIIKTNKKTGQPMI |
Function
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis
Protein Sequence
10
TDYTQQATQS
20
YGAYPTQPGQ
30
GYSQQSNQPY
40
GQQSYSGYGQ
50
SADTSGYGQS
60
SYGSSYGQTQ
70
NTGYGTQSAP
80
QGYGSTGGYG
90
SSQSSQSSYG
100
QQSSYPGYGQ
110
QPAPSSTSGS
120
YGGSSQSSSY
130
GQPQSGGYGQ
140
QSGYGGQQQS
150
YGQQQSSYNP
160
PQGYGQQNQY
170
NSSSGGGGGG
180
GGGNYGQDQS
190
SMSGGGGGGG
200
YGNQDQSGGG
210
GGGYGGGQQD
220
RGGRGRGGGG
230
GYNRSSGGYE
240
PRGRGGGRGG
250
RGGMGGSDRG
260
GFNKFGGPRD
270
QGSRHDSEQD
280
NSDNNTIFVQ
290
GLGENVTIES
300
VADYFKQIGI
310
IKTNKKTGQP
320
MINLYTDRET
330
GKLKGEATVS
340
FDDPPSAKAA
350
IDWFDGKEFS
360
GNPIKVSFAT
370
RRADFNRGGG
380
NGRGGRGRGG
390
PMGRGGYGGG
400
GSGGGGRGGF
410
PSGGGGGGGQ
420
QRAGDWKCPN
430
PTCENMNFSW
440
RSECNQCKAP
450
KPDGPGGGPG
460
GSHMGGNYGD
470
DRRGRGGYDR
480
GGYRGRGGDR
490
GGFRGGRGGG
500
DRGGFGPGKM
510
DSRGEHRQDR
RERPY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0044327 |
dendritic spine head |
| Cellular Component |
GO:0098982 |
GABA-ergic synapse |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0099524 |
postsynaptic cytosol |
| Cellular Component |
GO:0099523 |
presynaptic cytosol |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0035255 |
ionotropic glutamate receptor binding |
| Molecular Function |
GO:0140693 |
molecular condensate scaffold activity |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
| Molecular Function |
GO:0031489 |
myosin V binding |
| Molecular Function |
GO:0030331 |
nuclear estrogen receptor binding |
| Molecular Function |
GO:0046965 |
nuclear retinoid X receptor binding |
| Molecular Function |
GO:0046966 |
nuclear thyroid hormone receptor binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0003712 |
transcription coregulator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:1990000 |
amyloid fibril formation |
| Biological Process |
GO:0071277 |
cellular response to calcium ion |
| Biological Process |
GO:0010467 |
gene expression |
| Biological Process |
GO:0140694 |
membraneless organelle assembly |
| Biological Process |
GO:0048255 |
mRNA stabilization |
| Biological Process |
GO:1905168 |
positive regulation of double-strand break repair via homologous recombination |
| Biological Process |
GO:0051260 |
protein homooligomerization |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0043484 |
regulation of RNA splicing |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.