Search Results
Overview
| Uniprot ID | Q5PQX1 |
|---|---|
| Protein Name | Torsin-1A-interacting protein 1 |
| Gene Name | Tor1aip1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 177 | VTSQTVSKKTVRTPE |
| 309 | MAYNNIQKSDFGNQS |
Function
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina
Protein Sequence
10
MAGERWRAEG
20
LGEGWAIYVT
30
PRAPIREGRR
40
RLATQNGDGS
50
DAPAYETHPS
60
RHGRREVRFS
70
EEPPEVYGDF
80
EPRAAKERSP
90
GERRTPPEKF
100
RSDSAKEEVR
110
ESAYNLRSRQ
120
RRQRGPQEAE
130
EMKTRRSTRL
140
EQHSQQAQQQ
150
LSPATSGRGL
160
RDAQSLSEDR
170
GEDEPSSQPV
180
TSQTVSKKTV
190
RTPETSVMSE
200
DPISNLCRPP
210
LRSPRPDASI
220
VQHINPFEEG
230
ETEDDLESSY
240
SDVTIRIRSR
250
DSVESRDEAA
260
VAAGHHPDSL
270
WGLPHSRGDF
280
TAHENQPSLL
290
PTGCQKNPQE
300
WVEQAVRMRT
310
RMAYNNIQKS
320
DFGNQSPSTS
330
RQQAAVQPPD
340
ESSVKIKWWL
350
LILVAALAMG
360
IYWFFHTPVV
370
ETTAVQEFQN
380
QMKQLQSKYQ
390
SQDEKLWKRG
400
TTFLEKHLNS
410
SLPRPQPAIL
420
LLTAAQDAAE
430
VLKCLSEQIA
440
DAYSSFRSVR
450
AIRIDGAGKA
460
AQDSDLVKHE
470
VDQELTDGFR
480
NGQNAAVVHR
490
FESLPAGSTL
500
IFYKYCDHEN
510
AAFKDVALVL
520
TVLLEEQTLE
530
ASLGLKEIEE
540
KVRDFLKVKF
550
TSSDTANSYN
560
HMDPDKLNGL
570
WSRISHLVLP
580
VQPENALKAG
SCL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005637 | nuclear inner membrane |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0005521 | lamin binding |
| Biological Process | GO:0071763 | nuclear membrane organization |
| Biological Process | GO:0032781 | positive regulation of ATP-dependent activity |
| Biological Process | GO:0090435 | protein localization to nuclear envelope |
| Biological Process | GO:0034504 | protein localization to nucleus |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.