Search Results

Overview

Uniprot IDQ5PSV4
Protein NameBreast cancer metastasis-suppressor 1-like protein
Gene NameBRMS1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
193 LQSRKKRKDPFSPDK
240 TLGPHRVKTEPPVKL
246 VKTEPPVKLEKHLHS
249 EPPVKLEKHLHSARS
307 RPDGSKSKLYISQLQ

Function

Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth

Protein Sequence

10 MPVHSRGDKK 20 ETNHHDEMEV 30 DYAENEGSSS 40 EDEDTESSSV 50 SEDGDSSEMD 60 DEDCERRRME 70 CLDEMSNLEK 80 QFTDLKDQLY 90 KERLSQVDAK 100 LQEVIAGKAP 110 EYLEPLATLQ 120 ENMQIRTKVA 130 GIYRELCLES 140 VKNKYECEIQ 150 ASRQHCESEK 160 LLLYDTVQSE 170 LEEKIRRLEE 180 DRHSIDITSE 190 LWNDELQSRK 200 KRKDPFSPDK 210 KKPVVVSGPY 220 IVYMLQDLDI 230 LEDWTTIRKA 240 MATLGPHRVK 250 TEPPVKLEKH 260 LHSARSEEGR 270 LYYDGEWYIR 280 GQTICIDKKD 290 ECPTSAVITT 300 INHDEVWFKR 310 PDGSKSKLYI 320 SQLQKGKYSI KHS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:1902459 positive regulation of stem cell population maintenance
Cellular Component GO:0005634 nucleus
Cellular Component GO:0070822 Sin3-type complex
Molecular Function GO:0042826 histone deacetylase binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:1902455 negative regulation of stem cell population maintenance
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.