Search Results

Overview

Uniprot ID	Q5QD51
Protein Name	A-kinase anchor protein 12
Gene Name	Akap12
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
1028	ILQAVADKVKEESQV
1030	QAVADKVKEESQVPA
1488	KESTAIEKVLKAEPE
1491	TAIEKVLKAEPEILE
1502	EILELESKSNKIVLN
159	VGFKKVFKFVGFKFT
1664	QEEEMSTKSVKENKA
174	VKKDKNEKSDTVQLL
184	TVQLLTVKKDEGEGA
286	ETTSSFKKFFTHGWA
303	RKKTSFKKSKEDDLE
305	KTSFKKSKEDDLETA
496	LSSQERIKVQGSPLK
503	KVQGSPLKKLFSSSG
504	VQGSPLKKLFSSSGL
512	LFSSSGLKKLSGKKQ
791	EESWVSIKKFIPGRR

Function

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)

Protein Sequence

10 MGAGSSTEQR 20 SPEQPAGSDT 30 PSELVLSGHG 40 PAAEASGAAG 50 DPADADPATK 60 LPQKNGQLST 70 VNGVAEQGDV 80 HVQEENQEGQ 90 EEEVVDEDVG 100 QRESEDVREK 110 DRVEEMAANS 120 TAVEDITKDG 130 QEETSEIIEQ 140 IPASESNVEE 150 MVQPAESQAN 160 DVGFKKVFKF 170 VGFKFTVKKD 180 KNEKSDTVQL 190 LTVKKDEGEG 200 AEASVGAGDH 210 QEPSVETAVG 220 ESASKESELK 230 QSTEKQEGTL 240 KQEQSSTEIP 250 LQAESDQAAE 260 EEAKDEGEEK 270 QEKEPTKSPE 280 SPSSPVSSET 290 TSSFKKFFTH 300 GWAGWRKKTS 310 FKKSKEDDLE 320 TAEKRKEQEA 330 EKVDEEEKEK 340 TEPASEEQEP 350 AEDTDQARLS 360 ADYEKVELPL 370 EDQVGDLEAS 380 SEEKCAPLAT 390 EVFDEKMEAH 400 QEVVAEVHVS 410 TVEKTEEEQG 420 GGGEAEGGVV 430 VEGTGESLPP 440 EKLAEPQEVP 450 QEAEPAEELM 460 KSREMCVSGG 470 DHTQLTDLSP 480 EEKTLPKHPE 490 GIVSEVEMLS 500 SQERIKVQGS 510 PLKKLFSSSG 520 LKKLSGKKQK 530 GKRGGGGDEE 540 PGEYQHIHTE 550 SPESADEQKG 560 ESSASSPEEP 570 EETTCLEKGP 580 LEAPQDGEAE 590 EGTTSDGEKK 600 REGITPWASF 610 KKMVTPKKRV 620 RRPSESDKEE 630 ELEKVKSATL 640 SSTDSTVSEM 650 QDEVKTVGEE 660 QKPEEPKRRV 670 DTSVSWEALI 680 CVGSSKKRAR 690 KASSSDDEGG 700 PRTLGGDSHR 710 AEEASKDKEA 720 GTDAVPASTQ 730 EQDQAQGSSS 740 PEPAGSPSEG 750 EGVSTWESFK 760 RLVTPRKKSK 770 SKLEEKAEDS 780 SVEQLSTEIE 790 PSREESWVSI 800 KKFIPGRRKK 810 RADGKQEQAT 820 VEDSGPVEIN 830 EDDPDVPAVV 840 PLSEYDAVER 850 EKMEAQGNAE 860 LPQLLGAVYV 870 SEELSKTLVH 880 TVSVAVIDGT 890 RAVTSVEERS 900 PSWISASVTE 910 PLEHTAGEAM 920 PPVEEVTEKD 930 IIAEETPVLT 940 QTLPEGKDAH 950 DDMVTSEVDF 960 TSEAVTATET 970 SEALRTEEVT 980 EASGAEETTD 990 MVSAVSQLTD 1000 SPDTTEEATP 1010 VQEVEGGVLD 1020 TEEEERQTQA 1030 ILQAVADKVK 1040 EESQVPATQT 1050 VQRTGSKALE 1060 KVEEVEEDSE 1070 VLASEKEKDV 1080 MPKGPVQEAG 1090 AEHLAQGSET 1100 GQATPESLEV 1110 PEVTADVDHV 1120 ATCQVIKLQQ 1130 LMEQAVAPES 1140 SETLTDSETN 1150 GSTPLADSDT 1160 ADGTQQDETI 1170 DSQDSKATAA 1180 VRQSQVTEEE 1190 AATAQKEEPS 1200 TLPNNVPAQE 1210 EHGEEPGRDV 1220 LEPTQQELAA 1230 AAVPVLAKTE 1240 VGQEGEVDWL 1250 DGEKVKEEQE 1260 VFVHSGPNSQ 1270 KAADVTYDSE 1280 VMGVAGCQEK 1290 ESTEVQSLSL 1300 EEGEMETDVE 1310 KEKRETKPEQ 1320 VSEEGEQETA 1330 APEHEGTYGK 1340 PVLTLDMPSS 1350 ERGKALGSLG 1360 GSPSLPDQDK 1370 AGCIEVQVQS 1380 LDTTVTQTAE 1390 AVEKVIETVV 1400 ISETGESPEC 1410 VGAHLLPAEK 1420 SSATGGHWTL 1430 QHAEDTVPLG 1440 PESQAESIPI 1450 IVTPAPESTL 1460 HPDLQGEISA 1470 SQRERSEEED 1480 KPDAGPDADG 1490 KESTAIEKVL 1500 KAEPEILELE 1510 SKSNKIVLNV 1520 IQTAVDQFAR 1530 TETAPETHAY 1540 DSQTQVPAMQ 1550 ADSQGAQQML 1560 DKNESCQDET 1570 PSAAAQRGLA 1580 SPDRSGGMGS 1590 ASEMLAALAV 1600 ESAGVKVSIE 1610 KLPPQPKDQK 1620 EHAADGPQLQ 1630 SLAQAEASAS 1640 GNLTKESPDT 1650 NGPKLTEEGD 1660 APKVEVQEEE 1670 MSTKSVKENK 1680 AQAEEDLQEP KGDLAES

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0051602	response to electrical stimulus
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0007165	signal transduction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse
Molecular Function	GO:0008179	adenylate cyclase binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0051018	protein kinase A binding
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process	GO:0141156	cAMP/PKA signal transduction
Biological Process	GO:0071347	cellular response to interleukin-1
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0035733	hepatic stellate cell activation
Biological Process	GO:0050804	modulation of chemical synaptic transmission
Biological Process	GO:0043116	negative regulation of vascular permeability
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0061870	positive regulation of hepatic stellate cell migration
Biological Process	GO:1900143	positive regulation of oligodendrocyte apoptotic process
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0090036	regulation of protein kinase C signaling

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.