Search Results

Overview

Uniprot IDQ5QJE6
Protein NameDeoxynucleotidyltransferase terminal-interacting protein 2
Gene NameDNTTIP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 VTRSARAKASIQAAS
159 RIVLPTEKTTGARRS
220 QTEKKDSKIVPGNEK
227 KIVPGNEKQIVGTPV
316 EGKEINEKSSQLKNL
321 NEKSSQLKNLSELQD
345 RHSTPQNKNAVSVHS
384 NNKKSPIKASDLTKF
54 AESQTTGKQSLIPRT
558 STKAKLLKLTSSSID

Function

Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Protein Sequence

10 MVVTRSARAK 20 ASIQAASAES 30 SGQKSFAANG 40 IQAHPESSTG 50 SDARTTAESQ 60 TTGKQSLIPR 70 TPKARKRKSR 80 TTGSLPKGTE 90 PSTDGETSEA 100 ESNYSVSEHH 110 DTILRVTRRR 120 QILIACSPVS 130 SVRKKPKVTP 140 TKESYTEEIV 150 SEAESHVSGI 160 SRIVLPTEKT 170 TGARRSKAKS 180 LTDPSQESHT 190 EAISDAETSS 200 SDISFSGIAT 210 RRTRSMQRKL 220 KAQTEKKDSK 230 IVPGNEKQIV 240 GTPVNSEDSD 250 TRQTSHLQAR 260 SLSEINKPNF 270 YNNDFDDDFS 280 HRSSENILTV 290 HEQANVESLK 300 ETKQNCKDLD 310 EDANGITDEG 320 KEINEKSSQL 330 KNLSELQDTS 340 LQQLVSQRHS 350 TPQNKNAVSV 360 HSNLNSEAVM 370 KSLTQTFATV 380 EVGRWNNNKK 390 SPIKASDLTK 400 FGDCGGSDDE 410 EESTVISVSE 420 DMNSEGNVDF 430 ECDTKLYTSA 440 PNTSQGKDNS 450 VLLVLSSDES 460 QQSENSENEE 470 DTLCFVENSG 480 QRESLSGDTG 490 SLSCDNALFV 500 IDTTPGMSAD 510 KNFYLEEEDK 520 ASEVAIEEEK 530 EEEEDEKSEE 540 DSSDHDENED 550 EFSDEEDFLN 560 STKAKLLKLT 570 SSSIDPGLSI 580 KQLGGLYINF 590 NADKLQSNKR 600 TLTQIKEKKK 610 NELLQKAVIT 620 PDFEKNHCVP 630 PYSESKYQLQ 640 KKRRKERQKT 650 AGDGWFGMKA 660 PEMTNELKND 670 LKALKMRASM 680 DPKRFYKKND 690 RDGFPKYFQI 700 GTIVDNPADF 710 YHSRIPKKQR 720 KRTIVEELLA 730 DSEFRRYNRR 740 KYSEIMAEKA 750 ANAAGKKFRK KKKFRN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0042274 ribosomal small subunit biogenesis
Biological Process GO:0006396 RNA processing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.