Search Results
Overview
| Uniprot ID | Q5RJR2 |
|---|---|
| Protein Name | Twinfilin-1 |
| Gene Name | Twf1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 320 | HPKQHAHKQSFAKPK |
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)
Protein Sequence
10
MSHQTGIQAS
20
EDVKEIFARA
30
RNGKYRLLKI
40
SIENEQLVVG
50
SCSPPSDSWE
60
QDYDPFVLPL
70
LEDKQPCYVL
80
FRLDSQNAQG
90
YEWIFIAWSP
100
DHSHVRQKML
110
YAATRATLKK
120
EFGGGHIKDE
130
VFGTVKEDVS
140
LHGYRKYLLS
150
QSSPAPLTAA
160
EEELRQIKIS
170
EVQTDVSVDT
180
KHQTLQGVAF
190
PISRDAFQAL
200
EKLSKRQLNY
210
VQLEIDIKNE
220
TIILANTENT
230
ELKDLPKRIP
240
KDSARYHFFL
250
YKHSHEGDYL
260
ESIVFIYSMP
270
GYTCSIRERM
280
LYSSCKSPLL
290
DIVERQLQMD
300
VIRKIEIDNG
310
DELTADFLYD
320
EVHPKQHAHK
330
QSFAKPKGPA
340
GKRGIRRLIR
350
GPAEAEATTD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0004713 | protein tyrosine kinase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:1990708 | conditioned place preference |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
| Biological Process | GO:0061002 | negative regulation of dendritic spine morphogenesis |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0010591 | regulation of lamellipodium assembly |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.