Search Results
Overview
| Uniprot ID | Q5RJR8 |
|---|---|
| Protein Name | Leucine-rich repeat-containing protein 59 |
| Gene Name | Lrrc59 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | PVSFAQLKNLKWLDL |
| 111 | FAQLKNLKWLDLKDN |
| 135 | AGDCLDEKQCKQCAN |
| 201 | EEKERRRKEYDAQKA |
| 207 | RKEYDAQKASKREQE |
| 40 | KELAALPKATVLDLS |
| 7 | *MTKTGSKGGNLRDK |
| 71 | LVKLDLSKNKLQQLP |
| 73 | KLDLSKNKLQQLPAD |
Function
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity)
Protein Sequence
10
MTKTGSKGGN
20
LRDKLDGNEL
30
DLSLSDLNEV
40
PVKELAALPK
50
ATVLDLSCNK
60
LSTLPSDFCG
70
LTHLVKLDLS
80
KNKLQQLPAD
90
FGRLVNLQHL
100
DLLNNRLVTL
110
PVSFAQLKNL
120
KWLDLKDNPL
130
DPVLAKVAGD
140
CLDEKQCKQC
150
ANKVLQHMKA
160
VQADQERERQ
170
RRLEVEREAE
180
KKREAKQQAK
190
EAKERELRKR
200
EKAEEKERRR
210
KEYDAQKASK
220
REQEKKPKKE
230
TNQAPKSKSG
240
SRPRKPPPRK
250
HNRSWAVLKG
260
LLLLLLLCVA
270
GGLVVCRVTG
280
LQQQPLCTSV
290
NAIYDNAVQG
300
LRHHEILQWV
LQTDSQQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005635 | nuclear envelope |
| Biological Process | GO:0035556 | intracellular signal transduction |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.