Overview
| Uniprot ID | Q5RK19 |
|---|
| Protein Name | Vacuolar-sorting protein SNF8 |
|---|
| Gene Name | Snf8 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 13 |
VGAGAIAKKKLAEAK |
| 134 |
QVLKGRGKFAQDVSQ |
Function
Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)
Protein Sequence
10
MHRRGVGAGA
20
IAKKKLAEAK
30
YKERGTVLAE
40
DQLAQMSKQL
50
DMFKTNLEEF
60
ASKHKQEIRK
70
NPEFRVQFQD
80
MCATIGVDPL
90
ASGKGFWSEM
100
LGVGDFYYEL
110
GVQIIEVCLA
120
LKHRNGGLIT
130
LEELHQQVLK
140
GRGKFAQDVS
150
QDDLIRAIKK
160
LKALGTGFGI
170
IPVGGTYLIQ
180
SVPAELNMDH
190
TVVLQLAEKN
200
GYVTVSEIKA
210
SLKWETERAR
220
QVLEHLLKEG
230
LAWLDLQAPG
240
EAHYWLPALF
250
TDLYSQEISA
EEAKEVFP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0000814 |
ESCRT II complex |
| Cellular Component |
GO:0031902 |
late endosome membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0005667 |
transcription regulator complex |
| Molecular Function |
GO:0016247 |
channel regulator activity |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045022 |
early endosome to late endosome transport |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0016236 |
macroautophagy |
| Biological Process |
GO:0036258 |
multivesicular body assembly |
| Biological Process |
GO:0071985 |
multivesicular body sorting pathway |
| Biological Process |
GO:1903543 |
positive regulation of exosomal secretion |
| Biological Process |
GO:0010628 |
positive regulation of gene expression |
| Biological Process |
GO:0045732 |
positive regulation of protein catabolic process |
| Biological Process |
GO:0043328 |
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process |
GO:0042176 |
regulation of protein catabolic process |
| Biological Process |
GO:0061635 |
regulation of protein complex stability |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.