Overview
| Uniprot ID | Q5RK30 |
|---|
| Protein Name | Ribosome maturation protein SBDS |
|---|
| Gene Name | Sbds |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 151 |
VKPNKSTKQQALEVI |
| 98 |
GEVQVSDKERHTQLE |
Function
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity)
Protein Sequence
10
MSIFTPTNQI
20
RLTNVAVVRM
30
KRGGKRFEIA
40
CYKNKVVGWR
50
SGVEKDLDEV
60
LQTHSVFVNV
70
SKGQVAKKED
80
LISAFGTDDQ
90
TEICKQILTK
100
GEVQVSDKER
110
HTQLEQMFRD
120
IATIVADKCV
130
NPETKRPYTV
140
ILIERAMKDI
150
HYSVKPNKST
160
KQQALEVIKQ
170
LKEKMKIERA
180
HMRLRFLLPV
190
NEGKKLKEKL
200
KPLMKVVESE
210
DYSQQLEIVC
220
LIDPGCFREI
230
DELIKKETKG
240
KGSLEVLSLK
250
DVEEGDEKFE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Molecular Function |
GO:0019843 |
rRNA binding |
| Biological Process |
GO:0048539 |
bone marrow development |
| Biological Process |
GO:0030282 |
bone mineralization |
| Biological Process |
GO:0042256 |
cytosolic ribosome assembly |
| Biological Process |
GO:0002244 |
hematopoietic progenitor cell differentiation |
| Biological Process |
GO:0001833 |
inner cell mass cell proliferation |
| Biological Process |
GO:0030595 |
leukocyte chemotaxis |
| Biological Process |
GO:0007052 |
mitotic spindle organization |
| Biological Process |
GO:0006364 |
rRNA processing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.